An efficient synthesis of the C27-C45 fragment of lagunamide A, a cyclodepsipeptide with potent cytotoxic and antimalarial properties
| dc.citation.epage | 192 | en_US |
| dc.citation.issue | 2 | en_US |
| dc.citation.spage | 187 | en_US |
| dc.citation.volume | 25 | en_US |
| dc.citation.woscount | 0 | |
| dc.contributor.author | Liu, Hui-Ming | en_US |
| dc.contributor.author | Chang, Chieh-Yu | en_US |
| dc.contributor.author | Lai, Ya-Chi | en_US |
| dc.contributor.author | Yang, Mei-Due | en_US |
| dc.contributor.author | Chang, Ching-Yao | en_US |
| dc.contributor.department | 應用化學系 | zh_TW |
| dc.contributor.department | Department of Applied Chemistry | en_US |
| dc.date.accessioned | 2014-12-08T15:35:07Z | |
| dc.date.available | 2014-12-08T15:35:07Z | |
| dc.date.issued | 2014-01-31 | en_US |
| dc.description.abstract | An efficient and stereoselective synthesis of the entire C27-C45 moiety of lagunamide A has been achieved from 1-[(4S)-4-benzyl-2-thioxothiazolidin-3-yl]propan-1-one in six steps with 22% overall yield. The key step in the synthesis is an asymmetric acetal aldol reaction featuring the enantioselective addition of a chiral thiazolidinethione-derived titanium enolate to an acetal to establish the stereochemistry at C39. (C) 2013 Elsevier Ltd. All rights reserved. | en_US |
| dc.identifier.doi | 10.1016/j.tetasy.2013.11.020 | en_US |
| dc.identifier.issn | 0957-4166 | en_US |
| dc.identifier.journal | TETRAHEDRON-ASYMMETRY | en_US |
| dc.identifier.uri | http://dx.doi.org/10.1016/j.tetasy.2013.11.020 | en_US |
| dc.identifier.uri | https://ir.lib.nycu.edu.tw/handle/11536/23831 | |
| dc.identifier.wosnumber | WOS:000331684700012 | |
| dc.language.iso | en_US | en_US |
| dc.title | An efficient synthesis of the C27-C45 fragment of lagunamide A, a cyclodepsipeptide with potent cytotoxic and antimalarial properties | en_US |
| dc.type | Article | en_US |