Rapid construction of tetrahydropyridine scaffolds via formal imino Diels-Alder reactions of Schiff bases and Nazarov reagents
| dc.citation.epage | 8831 | en_US |
| dc.citation.issue | 39 | en_US |
| dc.citation.spage | 8827 | en_US |
| dc.citation.volume | 17 | en_US |
| dc.citation.woscount | 0 | en_US |
| dc.contributor.author | Wu, Yen-Ku | en_US |
| dc.contributor.author | Rawal, Viresh H. | en_US |
| dc.contributor.department | 應用化學系 | zh_TW |
| dc.contributor.department | Department of Applied Chemistry | en_US |
| dc.date.accessioned | 2019-12-13T01:09:53Z | |
| dc.date.available | 2019-12-13T01:09:53Z | |
| dc.date.issued | 2019-10-21 | en_US |
| dc.description.abstract | Described is a one-flask, two-step method for the synthesis of highly functionalized piperidines. The process involves formal [4 + 2] cycloadditions of Schiff bases and Nazarov reagents, followed by facile elaborations of the initial cycloadducts. Notably, these aza-annulations are facilitated by protic solvents and proceed smoothly under ambient conditions, without other additives. The synthetic utility of this annulation protocol is further showcased through a concise, convergent synthesis of (+/-)-tetrabenazine. | en_US |
| dc.identifier.doi | 10.1039/c9ob01880h | en_US |
| dc.identifier.issn | 1477-0520 | en_US |
| dc.identifier.journal | ORGANIC & BIOMOLECULAR CHEMISTRY | en_US |
| dc.identifier.uri | http://dx.doi.org/10.1039/c9ob01880h | en_US |
| dc.identifier.uri | https://ir.lib.nycu.edu.tw/handle/11536/153005 | |
| dc.identifier.wosnumber | WOS:000489910100006 | en_US |
| dc.language.iso | en_US | en_US |
| dc.title | Rapid construction of tetrahydropyridine scaffolds via formal imino Diels-Alder reactions of Schiff bases and Nazarov reagents | en_US |
| dc.type | Article | en_US |
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