A concise synthesis of 2-(2-aminothiophene)-benzimidazoles by one-pot multicomponent reaction
| dc.citation.epage | 13943 | en_US |
| dc.citation.issue | 33 | en_US |
| dc.citation.spage | 13934 | en_US |
| dc.citation.volume | 3 | en_US |
| dc.citation.woscount | 1 | |
| dc.contributor.author | Chen, Li-Hsun | en_US |
| dc.contributor.author | Chuang, Ying-Sheng | en_US |
| dc.contributor.author | Narhe, Bharat D. | en_US |
| dc.contributor.author | Sun, Chung-Ming | en_US |
| dc.contributor.department | 應用化學系 | zh_TW |
| dc.contributor.department | Department of Applied Chemistry | en_US |
| dc.date.accessioned | 2014-12-08T15:31:41Z | |
| dc.date.available | 2014-12-08T15:31:41Z | |
| dc.date.issued | 2013 | en_US |
| dc.description.abstract | A one-pot synthesis of 2-aminothiophene linked benzimidazoles was achieved by utilizing 2-cyanomethyl benzimidazoles in a modified Gewald multicomponent reaction. The synthetic strategy of the reaction involved treatment of 2-(cyanomethyl)-benzimdazole with aldehydes containing an active methylene group and sulfur powder under refluxing conditions. The multicomponent reaction proceeded via Knoevenagel condensation of 2-(cyanomethyl)-benzimdazole with aldehyde to generate an alpha,beta-unsaturated nitrile followed by cyclization with molecular sulfur under basic conditions to give biologically relevant 2-(2-aminothiophene)-benzimidazoles in good yields. | en_US |
| dc.identifier.doi | 10.1039/c3ra41545g | en_US |
| dc.identifier.issn | 2046-2069 | en_US |
| dc.identifier.journal | RSC ADVANCES | en_US |
| dc.identifier.uri | http://dx.doi.org/10.1039/c3ra41545g | en_US |
| dc.identifier.uri | https://ir.lib.nycu.edu.tw/handle/11536/22423 | |
| dc.identifier.wosnumber | WOS:000322464500053 | |
| dc.language.iso | en_US | en_US |
| dc.title | A concise synthesis of 2-(2-aminothiophene)-benzimidazoles by one-pot multicomponent reaction | en_US |
| dc.type | Article | en_US |