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An Inkjet-Printed Flexible Non-Enzymatic Lactate Sensor for Clinical Blood Plasma Test
(2020-04-01)
Huang, Yi-Syuan
;
Chen, Kuan-Yu
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Cheng, Yu-Ting
;
Lee, Chih-Kuo
;
Tsai, Hsiao-En
In this letter, we demonstrate a fully inkjet-printed electrochemical lactate sensor. The sensor is inkjet-printed on a flexible substrate, Kapton film, where silver nanoparticles (Ag NPs) are printed as conductive electrodes. The working and reference electrodes of the sensor are Ag NPs/NiO NPs/Polyurethane (PU) and Ag/AgCl(s)/PU layers respectively. The inkjet-printed PU film can not only prevent the annihilation of the Ag NPs resulting from the dissolution of Ag and the formation of AgCl in the phosphate-buffered saline (PBS) but also stabilize the lactic acid measurements by maintaining a potential variant within 2% at different lactate concentrations. The as-printed sensor exhibits a linear sensitivity of 8.86nA/mM/mm(2) (R=99.6%) in the range from 0.6 to 2.2 mM. Clinical blood plasma testing results show that the trends of lactic acid change in patients measured by the sensor are the same as the ones measured using the existing detection method, colorimetric assays, in a tertiary university-affiliated hospital.
Serial serologic changes of hepatitis D virus in chronic hepatitis B patients receiving nucleos(t)ides analogues therapy
(1970-01-01)
Jang, Tyng-Yuan
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Wei, Yu-Ju
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Hsu, Cheng-Ting
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Hsu, Po-Yao
;
Liu, Ta-Wei
Background and Aim The serial serologic changes of hepatitis D virus (HDV) infection among chronic hepatitis B virus (HBV) infected patients who received oral nucleotide/nucleoside analogues are elusive. Methods Serum anti-HDV and HDV RNA among chronic hepatitis B (CHB) patients were tested at the time of initiating anti-HBV therapy and subsequently during the follow-up period. Results The seropositive rate of anti-HDV and HDV RNA among 2850 CHB patients, was 2.7% and 0.9%, respectively. Factors associated with anti-HDV seropositivity were platelet counts (odds ratio [OR]/95% confidence intervals [CI]: 0.995/0.992-0.999; P = 0.006), HBV DNA levels (OR/CI: 0.81/0.70-0.94; P = 0.005), and hepatitis B e-antigen (HBeAg) seropositivity (OR/CI: 0.22/0.05-0.95; P = 0.04). The only factor associated with HDV RNA positivity among anti-HDV seropositive patients was age (OR/CI: 0.95/0.90-1.00; P = 0.03). The spontaneous clearance rate of serum anti-HDV antibody was 3.0 per 100 person-years with a median follow-up period of 3.5 years (range 2-12 years), whereas the seroclearance rate of HDV RNA was 4.3 per 100 person-years among anti-HDV seropositive patients after a median follow-up period of 6.0 years (range 2-11 years). A baseline anti-HDV titer < 0.5 cut-off index was the only factor predictive of anti-HDV seroclearance (hazard ratio [HR]/CI: 30.11/3.73-242.85; P = 0.001). Conclusions HDV infection was not common among patients treated for HBV in Taiwan. Seroclearance of anti-HDV and HDV RNA did occur over time, albeit the chance is rare.
Design of an LED Spot Light System with a Projection Distance of 10 km
(2019-10-01)
Wu, Chi-Shou
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Chen, Kuan-Yu
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Lee, Xuan-Hao
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Lin, Shih-Kang
;
Sun, Ching-Cherng
We designed a spot light system with an illumination range of 10 km. In the designed system, an appropriate white light-emitting diode (LED) was selected according to the exitance and injection power required. Subsequently, through a first-order optical design, the geometry of the lens and reflector was determined using geometrical calculation. Because the central illuminance of the projection spot of the reflector was 2.5 times that of the cover lens, we first considered the fabrication error of the reflector. According to the adjustment of the optimized distance between the white LED and reflector, we modified the design of the cover lens to fit the new location of the white LED. An LED spot light module containing 16 spot light units was used. The module's power injection was only 68.2 W. Because of the excellent performance of the designed system in terms of the divergence angle of the projection beam and maximum luminous intensity, which were 1.6 degrees and 2,840,000 cd, respectively, the projection distance of the LED spot light module was 3.37 Km, according to the ANSI regulation. Finally, a spot light system with nine modules and capable of achieving a projection distance of 10 km was successfully fabricated.
Advertisement recommendation based on personal interests and ad push fairness
(2019-01-01)
Liu, Duen-Ren
;
Liao, Yu-Shan
;
Chung, Ya-Han
;
Chen, Kuan-Yu
;
資訊管理與財務金融系註：原資管所+財金所
Purpose - Online advertisement brings huge revenue to many websites. There are many types of online advertisement; this paper aims to focus on the online banner ads which are usually placed in a particular news website. The investigated news website adopts a pay-per-ad payment model, where the advertisers are charged when they rent a banner from the website during a particular period. In this payment model, the website needs to ensure that the ad pushed frequency of each ad on the banner is similar. Under such advertisement push rules, an ad-recommendation mechanism considering ad push fairness is required. Design/methodology/approach - The authors proposed a novel ad recommendation method that considers both ad-push fairness and personal interests. The authors take every ad's exposure time into consideration and investigate users' three different usage experiences in the website to identify the main factors affecting the interests of users. Online ad recommendation is conducted on the investigated news website. Findings - The results of the experiments show that the proposed approach performs better than the traditional approach. This method can not only enhance the average click rate of all ads in the website but also ensure reasonable fairness of exposure frequency of each ad. The online experiment results demonstrate the effectiveness of this approach. Originality/value - Existing researches had not considered both the advertisement recommendation and ad-push fairness together. With the proposed novel ad recommendation model, the authors can improve the ad click-through rate of ads with reasonable push fairness. The website provider can thereby increase the commercial value of advertising and user satisfaction.
Ribavirin facilitates early viral kinetics in chronic hepatitis C patients receiving daclatasvir/asunaprevir
(1970-01-01)
Huang, Chung-Feng
;
Yeh, Ming-Lun
;
Huang, Ching-, I
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Liang, Po-Cheng
;
Lin, Yi-Hun
Background and Aim Ribavirin (RBV) remains crucial in difficult-to-cure chronic hepatitis C patients receiving directly acting antivirals (DAAs). The current study aimed to address whether RBV enhanced early viral kinetics in patients with DAAs. Methods Hepatitis C virus (HCV) genotype-1b patients were allocated to daclatasvir/asunaprevir +weight-based RBV (1000-1200 mg/day) for 12-24 weeks. HCV RNA levels were compared at day 1, week 1, week 2, and week 4 of treatment. Results The sustained virological response rate was 100% (67/67) and 96.7% (59/61) in the RBV and non-RBV group, respectively. The HCV RNA levels at treatment week 2 (W2) were significantly lower in the RBV group than in the non-RBV group (0.42 +/- 0.81 log IU/mL vs 0.79 +/- 1.03 log IU/mL, P = 0.04). Among the intermediate responders who remained to have detectable RNA after W1 of treatment, patients with RBV had a significantly higher rate of undetectable HCV RNA (71.4% vs 36.0%, P = 0.003) and lower HCV RNA level at W2 (0.55 +/- 0.89 log IU/mL vs 1.32 +/- 1.04 log IU/mL, P = 0.001). A more significant magnitude of HCV RNA reduction was also noted from baseline to day 1 (3.15 +/- 0.38 log IU/mL vs 2.80 +/- 0.70 log IU/mL, P = 0.009) and W1 to W2 (1.40 +/- 0.65 log IU/mL vs 0.88 +/- 0.78 log IU/mL, P = 0.007) in the RBV group compared to the non-RBV group among the intermediate responders. Logistic regression analysis revealed that adding RBV independently predicted undetectable HCV RNA at W2 (odds ratio/confidence interval: 4.74/1.54-14.57, P = 0.007) in the intermediate responders. Conclusions Adding RBV to DAAs improved early viral kinetic, in particular, for intermediate responders.
Churn prediction and social neighbour influences for different types of user groups in virtual worlds
(2019-06-01)
Liu, Duen-Ren
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Liao, Hsiu-Yu
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Chen, Kuan-Yu
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Chiu, Yi-Ling
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資訊管理與財務金融系註：原資管所+財金所
In virtual worlds (VWs), users have more VW games alternatives, whereas VW companies consequently suffer from high customer turnover rate and low customer loyalty. Therefore, building a churn prediction model to facilitate subsequent churn management and customer retention is important. The churn behaviours and the impact of social neighbour influences to customer churn may be different for different types of users. Accordingly, we segment users into stable, unstable, and solitary user groups according to their social contact behaviours in VWs. Novel segmentation-based churn prediction approaches are proposed for churn prediction in VWs by building prediction models for each type of user groups and considering the effect of social neighbour influences for different user groups. The proposed approaches are evaluated by conducting experiments with a dataset collected from a VW platform. The experimental results show different churn prediction performances under different user groups. The segmentation-based churn prediction approaches perform better than do general approaches without considering user groups. Moreover, the results also reveal that social neighbour influences have a positive impact on stable and unstable users. The proposed work contributes to investigating the social neighbour influences on churn prediction for different types of user groups in VWs.
Impact of Oxygen Vacancy on the Photo-Electrical Properties of In2O3-Based Thin-Film Transistor by Doping Ga
(2019-03-01)
Chen, Kuan-Yu
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Yang, Chih-Chiang
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Su, Yan-Kuin
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Wang, Zi-Hao
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Yu, Hsin-Chieh
In this study, amorphous indium gallium oxide thin-film transistors (IGO TFTs) were fabricated by co-sputtering. Three samples with different deposition powers of the In2O3 target, namely, sample A with 50 W deposition power, sample B with 60 W deposition power, and sample C with 70 W deposition power, were investigated. The device performance revealed that oxygen vacancies are strongly dependent on indium content. However, when the deposition power of the In2O3 target increased, the number of oxygen vacancies, which act as charge carriers to improve the device performance, increased. The best performance was recorded at a threshold voltage of 1.1 V, on-off current ratio of 4.5 x 10(6), and subthreshold swing of 3.82 V/dec in sample B. Meanwhile, the optical properties of sample B included a responsivity of 0.16 A/W and excellent ultraviolet-to-visible rejection ratio of 8 x 10(4). IGO TFTs may act as photodetectors according to the results obtained for optical properties.
An Online Activity Recommendation Approach based on the Dynamic Adjustment of Recommendation Lists
(2017-01-01)
Liu, Duen-Ren
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Chen, Kuan-Yu
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Chou, Yun-Cheng
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Lee, Jia-Huei
;
資訊管理與財務金融系註：原資管所+財金所
This research investigates an online recommendation method for new types of online news websites. Cross-domain analysis on user browsing news and the attending activities is conducted to predict user preferences on activities based on non-negative Matrix Factorization (NMF) and Latent Dirichlet Allocation (LDA) topic model. A novel approach is proposed for the dynamic adjustment of recommendation lists in order to tackle the issue of limited recommendation layouts. The existing studies have not addressed this issue. The proposed approach is implemented on an online news website and evaluated for online recommendations. The experiment results demonstrate that our method can predict user preferences on recommended activities and enhance the effectiveness of recommendations.
A Digital Reverse Current Self-calibration Technique in 90% High Efficiency Rectified Power Supply for Near Field Communication through Magnetic Field Induction
(2017-01-01)
Lin, Li-Chi
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Chen, Kuan-Yu
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Yang, Wen-Hau
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Huang, Ru-Yu
;
Chen, Ke-Horng
it is crucial in near field communication (NFC) controllers for power source transferred from mutual induction of coils when the devices are battery-off. NFC devices can be operated at the condition of low battery or even battery-off due to the requirement of payment any time. Thus, the proposed wireless power transfer (WPT) power supply can have high efficiency due to the remove of reverse leakage current by the digital reverse current self-calibration (DRCS). NFC standards including A, B, and F can be continuously supplied by the WPT supply system. The WPT power supply with the DRCS technique was fabricated in 0.25 mu m CMOS process can rectify AC source from induction of magnetic field to unregulated DC voltage source and to supply power the NFC controller through low dropout regulator (LDR). Moreover, test chip achieves as high as 92% voltage conversion ratio and 89.4 % power conversion efficiency (PCE) due to reduction of unnecessary current loss.
A novel "partial bypass" concept to augment the performance of air-cooled heat exchangers
(2012-09-01)
Wang, Chi-Chuan
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Chen, Kuan-Yu
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Liaw, Jane-Sunn
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Tseng, Chih-Yung
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機械工程學系
This study proposes a novel "partial bypass" concept which facilitates the heat transfer augmentation without the pumping power penalty. The basic idea is to introduce bypass cold stream which bypasses the front part of the heat exchanger and mixes with the hot stream across the front part of the heat exchanger, and the mixed stream flows through the rear part of the heat exchanger. Through this concept, heat transfer performance at the front part is slightly reduced but the rear part is substantially increased. The concept can be implemented with either maintaining the same total flowrate, heat transfer rate but accompanies with a much lower pressure drop or it can be applied with the same pumping power but accompanies with a much higher heat transfer rate. It is found that the "partial bypass" concept is especially fruitful for a heat exchanger with a comparatively large number of transfer unit (NTU). The concept is especially helpful in the design of a deep tube bank operated at lower frontal velocity. For validating the proposed concept, the calculation is also compared with the experimental measurements, and good agreement amid the calculations and measurements are reported. (C) 2012 Elsevier Ltd. All rights reserved.

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