標題: Nanomaterial Based Affinity Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry for Biomolecules and Pathogenic Bacteria
作者: Chiu, Tai-Chia
Huang, Li-Shing
Lin, Po-Chiao
Chen, Yu-Chie
Chen, Yu-Ju
Lin, Chun-Cheng
Chang, Huan-Tsung
應用化學系
應用化學系分子科學碩博班
Department of Applied Chemistry
Institute of Molecular science
關鍵字: Affinity probes;bacteria;biomoelcules;carbon nanotubes;gold nanoparticles;magnetic nanoparticles;MALDI;nanomaterials;proteins;peptides;SALDI
公開日期: 1-Jun-2007
摘要: This paper describes mass spectrometry (MS) using nanoparticles (NPs) for the analysis of biomolecules such as aminothiol compounds, drugs, peptides, proteins, and bacteria. Papers and patents dealing with preparation and use of several NPs in MS have been briefly reviewed, including carbon nanotubes, gold NPs, and magnetic NPs. The NPs or bioconjugated NPs were used for selective concentration and/or assisted matrices for desorption and ionization of analytes of interest. When compared to conventional organic matrixes, the NPs provide low MS background in low-mass region and low shot-to-shot variation. MS techniques using NPs and bioconjugated NPs for the analysis of disease-associated biomarkers and bacteria in real samples such as blood and urine are highlighted, showing the advantages of high sensitivity, reproducibility, and simplicity.
URI: http://dx.doi.org/10.2174/187221007780859618
http://hdl.handle.net/11536/10760
ISSN: 1872-2105
DOI: 10.2174/187221007780859618
期刊: RECENT PATENTS ON NANOTECHNOLOGY
Volume: 1
Issue: 2
起始頁: 99
結束頁: 111
Appears in Collections:Articles