標題: | iPTREE-STAB: interpretable decision tree based method for predicting protein stability changes upon mutations |
作者: | Huang, Liang-Tsung Gromiha, M. Michael Ho, Shinn-Ying 生物科技學系 生物資訊及系統生物研究所 Department of Biological Science and Technology Institude of Bioinformatics and Systems Biology |
公開日期: | 15-五月-2007 |
摘要: | We have developed a web server, iPTREE-STAB for discriminating the stability of proteins (stabilizing or destabilizing) and predicting their stability changes (AAG) upon single amino acid substitutions from amino acid sequence. The discrimination and prediction are mainly based on decision tree coupled with adaptive boosting algorithm, and classification and regression tree, respectively, using three neighboring residues of the mutant sit. along N- and C-terminals. Our method showed an accuracy of 82% for discriminating the stabilizing and destabilizing mutants, and a correlation of 0.70 for predicting protein stability changes upon mutations. |
URI: | http://dx.doi.org/10.1093/bioinformatics/btm100 http://hdl.handle.net/11536/10796 |
ISSN: | 1367-4803 |
DOI: | 10.1093/bioinformatics/btm100 |
期刊: | BIOINFORMATICS |
Volume: | 23 |
Issue: | 10 |
起始頁: | 1292 |
結束頁: | 1293 |
顯示於類別: | 期刊論文 |