完整後設資料紀錄
DC 欄位語言
dc.contributor.authorHsieh, Y. -Y.en_US
dc.contributor.authorWang, Y. -K.en_US
dc.contributor.authorChang, C. -C.en_US
dc.contributor.authorLin, C. -S.en_US
dc.date.accessioned2014-12-08T15:14:49Z-
dc.date.available2014-12-08T15:14:49Z-
dc.date.issued2007-02-01en_US
dc.identifier.issn1360-9947en_US
dc.identifier.urihttp://dx.doi.org/10.1093/molehr/gal099en_US
dc.identifier.urihttp://hdl.handle.net/11536/11187-
dc.description.abstractEndometriosis and leiomyoma are both common estrogen-related gynaecological diseases. We aimed to elucidate the association of estrogen receptor alpha (ER alpha)-351 A > G (XbaI) and -397 T > C (PvuII) gene polymorphisms with endometriosis and leiomyoma. Women were divided into three groups: (i) severe endometriosis (n = 112), (ii) leiomyoma (n = 106) and (iii) normal controls (n = 110). Genomic DNA was obtained from peripheral leukocytes. ER alpha-351 A/G XbaI and -397 T/C PvuII polymorphisms were assayed by the method of PCR and restriction fragment length polymorphism (RFLP). Genotypes and allelic frequencies in each group were compared. The genotype/allele frequencies of ER alpha-351 and -397 polymorphisms in endometriosis or leiomyoma groups were different from those of normal controls. ER alpha mutant-related genotypes/alleles (-351G and -397C) presented higher percentages in the endometriosis/leiomyoma population compared with normal controls. Proportions of ER alpha-351 AA/AG/GG genotypes and A/G alleles in each group were (i) 26.8/57.1/16.1 and 55.4/44.6%; (ii) 19.8/52.8/27.4 and 46.2/53.8% and (iii) 33.6/64.6/1.8 and 65.9/34.1%. Proportions of ER alpha-397 TT/TC/CC genotypes and T/C alleles in each group were (i) 24.1/60.7/15.2 and 54.5/45.5%; (ii) 23.6/70.8/5.6 and 59/41% and (iii) 54.5/40/5.5 and 74.5/25.5%. We concluded that ER alpha-351 XbaI*G- and -397 PvuII*C-related genotypes/alleles were correlated with higher susceptibilities of endometriosis or leiomyoma, which might be associated with related pathogeneses.en_US
dc.language.isoen_USen_US
dc.subjectendometriosisen_US
dc.subjectestrogen receptoren_US
dc.subjectleiomyomaen_US
dc.subjectpolymorphismen_US
dc.subjectsingle-nucleotide polymorphismen_US
dc.titleEstrogen receptor alpha-351 XbaI*G and -397 PvuII*C-related genotypes and alleles are associated with higher susceptibilities of endometriosis and leiomyomaen_US
dc.typeArticleen_US
dc.identifier.doi10.1093/molehr/gal099en_US
dc.identifier.journalMOLECULAR HUMAN REPRODUCTIONen_US
dc.citation.volume13en_US
dc.citation.issue2en_US
dc.citation.spage117en_US
dc.citation.epage122en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000243590700005-
dc.citation.woscount31-
顯示於類別:期刊論文


文件中的檔案:

  1. 000243590700005.pdf

若為 zip 檔案,請下載檔案解壓縮後,用瀏覽器開啟資料夾中的 index.html 瀏覽全文。