完整後設資料紀錄
DC 欄位 | 值 | 語言 |
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dc.contributor.author | Hsieh, Y. -Y. | en_US |
dc.contributor.author | Wang, Y. -K. | en_US |
dc.contributor.author | Chang, C. -C. | en_US |
dc.contributor.author | Lin, C. -S. | en_US |
dc.date.accessioned | 2014-12-08T15:14:49Z | - |
dc.date.available | 2014-12-08T15:14:49Z | - |
dc.date.issued | 2007-02-01 | en_US |
dc.identifier.issn | 1360-9947 | en_US |
dc.identifier.uri | http://dx.doi.org/10.1093/molehr/gal099 | en_US |
dc.identifier.uri | http://hdl.handle.net/11536/11187 | - |
dc.description.abstract | Endometriosis and leiomyoma are both common estrogen-related gynaecological diseases. We aimed to elucidate the association of estrogen receptor alpha (ER alpha)-351 A > G (XbaI) and -397 T > C (PvuII) gene polymorphisms with endometriosis and leiomyoma. Women were divided into three groups: (i) severe endometriosis (n = 112), (ii) leiomyoma (n = 106) and (iii) normal controls (n = 110). Genomic DNA was obtained from peripheral leukocytes. ER alpha-351 A/G XbaI and -397 T/C PvuII polymorphisms were assayed by the method of PCR and restriction fragment length polymorphism (RFLP). Genotypes and allelic frequencies in each group were compared. The genotype/allele frequencies of ER alpha-351 and -397 polymorphisms in endometriosis or leiomyoma groups were different from those of normal controls. ER alpha mutant-related genotypes/alleles (-351G and -397C) presented higher percentages in the endometriosis/leiomyoma population compared with normal controls. Proportions of ER alpha-351 AA/AG/GG genotypes and A/G alleles in each group were (i) 26.8/57.1/16.1 and 55.4/44.6%; (ii) 19.8/52.8/27.4 and 46.2/53.8% and (iii) 33.6/64.6/1.8 and 65.9/34.1%. Proportions of ER alpha-397 TT/TC/CC genotypes and T/C alleles in each group were (i) 24.1/60.7/15.2 and 54.5/45.5%; (ii) 23.6/70.8/5.6 and 59/41% and (iii) 54.5/40/5.5 and 74.5/25.5%. We concluded that ER alpha-351 XbaI*G- and -397 PvuII*C-related genotypes/alleles were correlated with higher susceptibilities of endometriosis or leiomyoma, which might be associated with related pathogeneses. | en_US |
dc.language.iso | en_US | en_US |
dc.subject | endometriosis | en_US |
dc.subject | estrogen receptor | en_US |
dc.subject | leiomyoma | en_US |
dc.subject | polymorphism | en_US |
dc.subject | single-nucleotide polymorphism | en_US |
dc.title | Estrogen receptor alpha-351 XbaI*G and -397 PvuII*C-related genotypes and alleles are associated with higher susceptibilities of endometriosis and leiomyoma | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1093/molehr/gal099 | en_US |
dc.identifier.journal | MOLECULAR HUMAN REPRODUCTION | en_US |
dc.citation.volume | 13 | en_US |
dc.citation.issue | 2 | en_US |
dc.citation.spage | 117 | en_US |
dc.citation.epage | 122 | en_US |
dc.contributor.department | 生物科技學系 | zh_TW |
dc.contributor.department | Department of Biological Science and Technology | en_US |
dc.identifier.wosnumber | WOS:000243590700005 | - |
dc.citation.woscount | 31 | - |
顯示於類別: | 期刊論文 |