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dc.contributor.authorSu, Chun-Huien_US
dc.contributor.authorHsieh, Bor-Tsungen_US
dc.contributor.authorLeung, Stephen-Wanen_US
dc.contributor.authorWu, Chiung-Jenen_US
dc.contributor.authorChiu, Sheng-Yien_US
dc.contributor.authorLin, Chih-Shengen_US
dc.date.accessioned2014-12-08T15:14:58Z-
dc.date.available2014-12-08T15:14:58Z-
dc.date.issued2007en_US
dc.identifier.issn0955-3002en_US
dc.identifier.urihttp://hdl.handle.net/11536/11252-
dc.identifier.urihttp://dx.doi.org/10.1080/09553000701596126en_US
dc.description.abstractPurpose: Molecular mechanisms by which balloon angioplasty injury-induced neointimal hyperplasia can be reduced by intravascular brachytherapy are unclear. We investigated the role of nuclear factor-kappaB (NF-B-K) in neointimal hyperplasia following intracoronary irradiation. Materials and methods: Fifty-four coronary arteries from 30 pigs were divided into 6 groups: sham control, balloon angioplasty injury alone, beta-irradiation at doses of 14 or 20 Gy, and 14 or 20 Gy beta-irradiation immediately followed by balloon injury. Coronary arteries were injured by overstretch balloon angioplasty and then the arteries were irradiated using a Rhenium-188 (188 Re) b-emitting solution-filled balloon. Pigs were scarified one day or one week after coronary interventions for molecular detection and six weeks after the procedures for histological examination. Results: Six weeks after coronary interventions, the histological results show that balloon angioplasty injury had induced intimal hyperplasia in coronary artery but the response was significantly reduced by 28% and 60% when the injury was immediately treated by 14 and 20 Gy 188 Re beta-irradiation, respectively. The expression of arterial NF-B-K p65, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) were detected at one day and one week after the procedures. The treatment of balloon injury could significantly induce the NF-kB p65 expression in both gene and protein levels, and such induction could be significantly reduced by 188 Re beta-irradiation at dose of 20 Gy. However, the similar result on the regulation of gene expression affected by the b- irradiation could not be observed in ICAM-1 and VCAM-1. Conclusion: The inhibitory effect of intracoronary brachytherapy on neointimal formation following overstretch balloon angioplasty could involve inhibition of NF-kB p65.en_US
dc.language.isoen_USen_US
dc.subjectNF-kappa Ben_US
dc.subjectcoronary arteryen_US
dc.subjectrestenosisen_US
dc.subjectrhenium-188en_US
dc.subjectintracoronary brachytherapyen_US
dc.titleIncreased expression of nuclear NF-kappa B after coronary artery balloon injury can be inhibited by intracoronary beta-irradiationen_US
dc.typeArticleen_US
dc.identifier.doi10.1080/09553000701596126en_US
dc.identifier.journalINTERNATIONAL JOURNAL OF RADIATION BIOLOGYen_US
dc.citation.volume83en_US
dc.citation.issue10en_US
dc.citation.spage707en_US
dc.citation.epage716en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000250373600007-
dc.citation.woscount2-
Appears in Collections:Articles