标题: | Kappa-alpha plot derived structural alphabet and BLOSUM-like substitution matrix for rapid search of protein structure database |
作者: | Tung, Chi-Hua Huang, Jhang-Wei Yang, Jinn-Moon 生物科技学系 生物资讯及系统生物研究所 Department of Biological Science and Technology Institude of Bioinformatics and Systems Biology |
公开日期: | 2007 |
摘要: | We present a novel protein structure database search tool, 3D- BLAST, that is useful for analyzing novel structures and can return a ranked list of alignments. This tool has the features of BLAST ( for example, robust statistical basis, and effective and reliable search capabilities) and employs a kappa-alpha (kappa, alpha) plot derived structural alphabet and a new substitution matrix. 3D- BLAST searches more than 12,000 protein structures in 1.2 s and yields good results in zones with low sequence similarity. |
URI: | http://hdl.handle.net/11536/11253 http://dx.doi.org/10.1186/gb-2007-8-3-r31 |
ISSN: | 1474-760X |
DOI: | 10.1186/gb-2007-8-3-r31 |
期刊: | GENOME BIOLOGY |
Volume: | 8 |
Issue: | 3 |
显示于类别: | Articles |
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