Phenylalanine 445 within oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae influences C-ring cyclization and deprotonation reactions

doi:10.1021/ol061549r

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DC 欄位	值	語言
dc.contributor.author	Wu, Tung-Kung	en_US
dc.contributor.author	Liu, Yuan-Ting	en_US
dc.contributor.author	Chiu, Feng-Hsuan	en_US
dc.contributor.author	Chang, Cheng-Hsiang	en_US
dc.date.accessioned	2014-12-08T15:15:38Z	-
dc.date.available	2014-12-08T15:15:38Z	-
dc.date.issued	2006-10-12	en_US
dc.identifier.issn	1523-7060	en_US
dc.identifier.uri	http://dx.doi.org/10.1021/ol061549r	en_US
dc.identifier.uri	http://hdl.handle.net/11536/11677	-
dc.description.abstract	We describe the Saccharomyces cerevisiae oxidosqualene - lanosterol cyclase Phe445 site-saturated mutants that generate truncated tricyclic and altered deprotonation product profiles. Among these mutants, only polar side-chain group substitutions genetically complemented yeast viability and produced spatially related product diversity, supporting the Johnson model that cation - pi interactions between a carbocationic intermediate and an enzyme can be replaced by an electrostatic or polar side chain to stabilize the cationic intermediate, but with product differentiation.	en_US
dc.language.iso	en_US	en_US
dc.title	Phenylalanine 445 within oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae influences C-ring cyclization and deprotonation reactions	en_US
dc.type	Article	en_US
dc.identifier.doi	10.1021/ol061549r	en_US
dc.identifier.journal	ORGANIC LETTERS	en_US
dc.citation.volume	8	en_US
dc.citation.issue	21	en_US
dc.citation.spage	4691	en_US
dc.citation.epage	4694	en_US
dc.contributor.department	生物科技學系	zh_TW
dc.contributor.department	Department of Biological Science and Technology	en_US
dc.identifier.wosnumber	WOS:000241030900006	-
dc.citation.woscount	16	-
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