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dc.contributor.authorLee, TYen_US
dc.contributor.authorHorng, JTen_US
dc.contributor.authorJuan, HFen_US
dc.contributor.authorHuang, HDen_US
dc.contributor.authorWu, LCen_US
dc.contributor.authorTsai, MFen_US
dc.contributor.authorHuang, HCen_US
dc.date.accessioned2014-12-08T15:16:11Z-
dc.date.available2014-12-08T15:16:11Z-
dc.date.issued2006-07-15en_US
dc.identifier.issn0192-8651en_US
dc.identifier.urihttp://dx.doi.org/10.1002/jcc.20417en_US
dc.identifier.urihttp://hdl.handle.net/11536/12025-
dc.description.abstractProteins "work together" by actually binding to form multicomponent complexes that carry out specific functions. Proteomic analyses based on the mass spectrum are now key methods to determine the components in protein complexes. The protein-protein interaction or functional association may be known to exist among the extracted protein spots while analyzing the proteins on the 2D gel. In this study, we develop an agent-based system, namely AgentMultiProtIdent, which integrated two protein identification tools and a variety of databases storing relations among proteins and used to discover protein-protein interactions and protein functional associations, and identify protein complexes and proteins with multiple peptide mass fingerprints as input. The system takes Multiple Peptide Mass Fingerprints (PMFs) as a whole in the protein complex or protein identification. With the relations among proteins, it may greatly improve the accuracy of identification of protein complexes. Also, possible relationship of the multiple peptide mass fingerprints, such as ontology relation, can be discovered by our system, especially in the identification of protein complexes.en_US
dc.language.isoen_USen_US
dc.subjectagent-based systemen_US
dc.subjectbioinformaticsen_US
dc.subjectproteomicsen_US
dc.subjectpeptide mass fingerprintsen_US
dc.subjectMSen_US
dc.titleAn agent-based system to discover protein-protein interactions, identify protein complexes and proteins with multiple peptide mass fingerprintsen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/jcc.20417en_US
dc.identifier.journalJOURNAL OF COMPUTATIONAL CHEMISTRYen_US
dc.citation.volume27en_US
dc.citation.issue9en_US
dc.citation.spage1020en_US
dc.citation.epage1032en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.department生物資訊及系統生物研究所zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.contributor.departmentInstitude of Bioinformatics and Systems Biologyen_US
dc.identifier.wosnumberWOS:000237607200003-
dc.citation.woscount2-
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