標題: | Optimal detection angle in sub-diffraction resolution photothermal microscopy: application for high sensitivity imaging of biological tissues |
作者: | Miyazaki, Jun Tsurui, Hiromichi Kawasumi, Koshi Kobayashi, Takayoshi 電子物理學系 Department of Electrophysics |
公開日期: | 11-八月-2014 |
摘要: | We evaluated the optimal detection angle for maximizing the signal to noise ratio (SNR) in sub-diffraction resolution photothermal microscopy. The angular dependent photothermal signal was calculated based on scattering theory using the temporally modulated Yukawa potential, and its detection angle and modulation frequency dependencies were analyzed. We verified the theoretical findings by imaging gold nanoparticles using laser diode based photothermal microscopy with balanced detection scheme. High-sensitivity (SNR similar to 40) photothermal biological imaging of a mouse brain was also demonstrated. |
URI: | http://dx.doi.org/10.1364/OE.22.018833 http://hdl.handle.net/11536/124169 |
ISSN: | 1094-4087 |
DOI: | 10.1364/OE.22.018833 |
期刊: | OPTICS EXPRESS |
Volume: | 22 |
Issue: | 16 |
起始頁: | 0 |
結束頁: | 0 |
顯示於類別: | 期刊論文 |