標題: Thermodynamic Insight into Protein Aggregation Using a Kinetic Ising Model
作者: Tsai, Min-Yeh
Yuan, Jian-Min
Lin, Sheng-Hsien
應用化學系
Department of Applied Chemistry
關鍵字: Protein aggregation;Thermodynamics;Kinetics;Ising model
公開日期: 1-Jan-2015
摘要: In this work, we present a kinetic analysis for protein aggregation using the kinetic Ising model, which serves as a new application of a previously proposed model [Liang et al., J. Chin. Chem. Soc. 2003, 50, 335]. Considering protein as a single spin unit, we map two states of a unit to the aggregation-prone (AP) and the fibril (F) states. This work shows that the model can successfully capture the nucleation-growth features of protein aggregation from experiments, which offers thermodynamic interpretations of aggregation properties, such as lag-time and fibril stability.
URI: http://dx.doi.org/10.1002/jccs.201400272
http://hdl.handle.net/11536/124243
ISSN: 0009-4536
DOI: 10.1002/jccs.201400272
期刊: JOURNAL OF THE CHINESE CHEMICAL SOCIETY
Volume: 62
起始頁: 21
結束頁: 25
Appears in Collections:Articles