標題: Sensitivity enhancement of photothermal microscopy with radially segmented balanced detection
作者: Miyazaki, Jun
Tsurui, Hiromichi
Kawasumi, Koshi
Kobayashi, Takayoshi
電子物理學系
Department of Electrophysics
公開日期: 15-Feb-2015
摘要: A novel detection method is proposed for highly sensitive photothermal microscopic imaging. This method is based on the characteristics of an angular-dependent photothermal signal; it improves signal intensity by up to two times and rejects the intensity noise of the probe beam. The subdiffraction resolution photothermal imaging of mouse skin melanoma is demonstrated using a laser diode-based photothermal microscopy system to evaluate this method. We confirm that the signal intensity is enhanced 1.7 times compared with the conventional detection method. Moreover, the intensity noise of the laser diode used for the probe beam is effectively reduced by approximately 31 dB, even for a sample with non-uniformity of the refractive index and stationary absorption. This method is implemented by means of a commonly used balanced detector and is thus potentially useful for high-speed imaging. (C) 2015 Optical Society of America
URI: http://dx.doi.org/10.1364/OL.40.000479
http://hdl.handle.net/11536/124323
ISSN: 0146-9592
DOI: 10.1364/OL.40.000479
期刊: OPTICS LETTERS
Volume: 40
起始頁: 479
結束頁: 482
Appears in Collections:Articles