標題: Ndt80p is involved in L-sorbose utilization through regulating SOU1 in Candida albicans
作者: Lo, Hsiu-Jung
Chu, Wen-Li
Liou, Ci-Hong
Huang, Szu-Hsuan
Khoo, Kay-Hooi
Yang, Yun-Liang
生物科技學系
分子醫學與生物工程研究所
Department of Biological Science and Technology
Institute of Molecular Medicine and Bioengineering
關鍵字: Yeast;2D-PAGE analysis;NDT80;Candida
公開日期: 1-Jan-2015
摘要: Ndt80p, a known transcriptional factor, regulates various targets involved in stress responses, filamentous growth, and virulence in Candida albicans. Potential targets of Ndt80p have been identified at the transcriptional level. The present study was conducted to identify genes regulated by Ndt80p from the protein level. We found that the levels of Ahp1p, Fma1p, Hsp21p, Rfa2p, Snz1p, Sod1p, Soul p, Trp99p, orf19.251, orf19.1862, and orf19.5620, were affected by the null mutation of NDT80 by two-dimensional polyacrylamide gel-electrophoresis analysis. Among the 11 proteins, all but Sou1p and Rfa2p are suggested to be involved in known functions of Ndt80p. Here, we demonstrate that Ndt80p plays a role in t-sorbose utilization through regulating SOU1 in C. albicans. (C) 2014 Elsevier GmbH. All rights reserved.
URI: http://dx.doi.org/10.1016/j.ijmm.2014.11.001
http://hdl.handle.net/11536/124412
ISSN: 1438-4221
DOI: 10.1016/j.ijmm.2014.11.001
期刊: INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
Volume: 305
起始頁: 170
結束頁: 173
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