標題: Surface characteristics and biofunctionality of a novel high-performance, hydrophilic Jeffamine-added fluoro-containing polyimide for biomedical applications
作者: Lo, Teng-Yuan
Wang, Yen-Jen
Liu, Dean-Mo
Whang, Wha-Tzong
材料科學與工程學系
Department of Materials Science and Engineering
關鍵字: Fluoro-containing PI;Jeffamine;6FPI-J(x) series;Biocompatibility;Surface biofunctionality
公開日期: 24-Jan-2015
摘要: A brand-new class of Jeffamine-modified fluorocontaining polyimide (6FPI-J(x) series, where x ranges from 10, 20, and 30 % by weight) was developed in this study. The existing pristine fluoro-containing polyimide (6FPI) is a flexible and high-performance polymer with low surface energy for advanced engineering applications. Although it has been considered a promising biomaterial for its good blood compatibility, it has known to be toxic to normal cells. Here, we modified 6FPI [with -C (CF3)(2)-group on backbone] with a hydrophilic diamine monomer, Jeffamine, denoted as 6FPI-J(x), where x is the molar percentage of the total diamines. The newly synthesized 6FPI-J(x) series was systematically characterized in terms of surface properties included surface texture, chemistry, potential, and charging. Besides, the 6FPI-J(x) copolymer exhibited good mechanical and stability as pristine 6FPI. With the addition of Jeffamine (x=10 %), 6FPI-J(10) displayed considerably improved blood and cell compatibility compared to 6FPI, which was explainable as a combined effect of morphological texture and chemical environment of resulting surface. The new class of 6FPI-J(x) exhibited excellent solubility toward a number of organic solvents, which rendered the 6FPI-J(10) a great potential candidate as a biocompatible coating for implantable medical devices and also for potential therapeutic applications.
URI: http://dx.doi.org/10.1007/s10965-014-0628-8
http://hdl.handle.net/11536/124582
ISSN: 1022-9760
DOI: 10.1007/s10965-014-0628-8
期刊: JOURNAL OF POLYMER RESEARCH
Volume: 22
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