一款應用於生醫檢測之系統可程式化生醫晶片

Abstract

在本篇論文中，我們提出了一款應用於生醫檢測之系統可程式化生醫晶片，這個系統整合很多的功能，包含液珠位置感測、液珠移動規劃、驅動以及高解析度的量測窗口，這種新穎的可程式化生醫晶片解決許多傳統上的發展瓶頸。再者，每一個微電極單元使用感測電路，實現了液珠位置、種類辨識以及自我測試電路的正確性。我們也設計一個友善的圖形化使用者介面來達成即時的規劃、量測、也能將目前液珠的狀況顯示在螢幕上。我們使用台積電0.35μm CMOS 製程。量測結果顯示，微液珠可以如使用者規劃所操作。這些實驗結果充分凸顯出，本文所提出之系統可程式化生醫晶片能實現簡易操縱、使用者可程式化、擴展性、易於監視於系統自動化整合，這個系統可以用非常有效的方式被用於大量的生物檢測及巨量資料分析。

In this thesis, a system integration of Field-Programmable Lab-on-a-Chip (FPLOC) which is applied for biomedical detection is proposed. This work integrates many functions, including droplet location sensing, droplet pattern planning, actuation and high resolution measurement window. This novel FPLOC resolves bottleneck of traditional development. Furthermore, microelectrode cell employs the sensing circuit, forms droplet location/ category sensing, built-in self-test (BIST) for chip-testing. We realize a friendly graphical user interface (GUI) to achieve real-time programmer, measurement and droplet status monitor on the screen. The system has been implemented with TSMC 0.35um CMOS technology. The measurement results show droplet operates can be programmable by user planning. Those results highlight that our design can achieve easy-control, user programmability, scalability and observability for system automation integration. This work provides a foundation for the huge amount of bioassays and big-data analysis in a very efficient and effective way.