標題: | Biothiol-triggered, self-disassembled silica nanobeads for intracellular drug delivery |
作者: | Huang, Xin-Chun Wu, Li-Bang Hsu, Jen-Fang Shigeto, Shinsuke Hsu, Hsin-Yun 應用化學系 應用化學系分子科學碩博班 Department of Applied Chemistry Institute of Molecular science |
關鍵字: | Drug delivery;Silica nanoparticles;Sol-gel processes;Self-disassembly;Biothiols |
公開日期: | 1-九月-2015 |
摘要: | Silica-based nanomaterials have demonstrated great potential in biomedical applications due to their chemical inertness. However, the degradability and endosomal trapping issues remain as rate-limiting barriers during their innovation. In this study, we provide a simple yet novel sol-gel approach to construct the redox-responsive silica nanobeads (ReSiNs), which could be rapidly disassembled upon redox gradient for intracellular drug delivery. The disulfide-linked scaffold of the nanobead was synthesized by employing the dithiobis-(succinimidyl propionate) to bridge (3-aminopropyI)-trimethoxysilane. Such silica matrix could be efficiently disrupted in response to intracellular glutathione, resulting in drug release and collapse of entire nanocarrier. Moreover, the ReSiNs exhibited insignificant cytotoxicity before and after the degradation. These results indicated the potential of using ReSiNs as a novel silica-based, biothiol-degradable nanoplatform for future drug delivery. (C) 2015 Acts Materialia Inc. Published by Elsevier Ltd. All rights reserved. |
URI: | http://dx.doi.org/10.1016/j.actbio.2015.05.006 http://hdl.handle.net/11536/128143 |
ISSN: | 1742-7061 |
DOI: | 10.1016/j.actbio.2015.05.006 |
期刊: | ACTA BIOMATERIALIA |
Volume: | 23 |
起始頁: | 263 |
結束頁: | 270 |
顯示於類別: | 期刊論文 |