標題: Biothiol-triggered, self-disassembled silica nanobeads for intracellular drug delivery
作者: Huang, Xin-Chun
Wu, Li-Bang
Hsu, Jen-Fang
Shigeto, Shinsuke
Hsu, Hsin-Yun
應用化學系
應用化學系分子科學碩博班
Department of Applied Chemistry
Institute of Molecular science
關鍵字: Drug delivery;Silica nanoparticles;Sol-gel processes;Self-disassembly;Biothiols
公開日期: 1-Sep-2015
摘要: Silica-based nanomaterials have demonstrated great potential in biomedical applications due to their chemical inertness. However, the degradability and endosomal trapping issues remain as rate-limiting barriers during their innovation. In this study, we provide a simple yet novel sol-gel approach to construct the redox-responsive silica nanobeads (ReSiNs), which could be rapidly disassembled upon redox gradient for intracellular drug delivery. The disulfide-linked scaffold of the nanobead was synthesized by employing the dithiobis-(succinimidyl propionate) to bridge (3-aminopropyI)-trimethoxysilane. Such silica matrix could be efficiently disrupted in response to intracellular glutathione, resulting in drug release and collapse of entire nanocarrier. Moreover, the ReSiNs exhibited insignificant cytotoxicity before and after the degradation. These results indicated the potential of using ReSiNs as a novel silica-based, biothiol-degradable nanoplatform for future drug delivery. (C) 2015 Acts Materialia Inc. Published by Elsevier Ltd. All rights reserved.
URI: http://dx.doi.org/10.1016/j.actbio.2015.05.006
http://hdl.handle.net/11536/128143
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2015.05.006
期刊: ACTA BIOMATERIALIA
Volume: 23
起始頁: 263
結束頁: 270
Appears in Collections:Articles