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dc.contributor.authorSu, Heng-Tsanen_US
dc.contributor.authorTsai, May-Jywanen_US
dc.contributor.authorChang, Gao-Fongen_US
dc.contributor.authorHung, Chen-Hsiungen_US
dc.contributor.authorLin, Hung-Chengen_US
dc.contributor.authorChou, Che-Yeuen_US
dc.contributor.authorHuang, Ding-Wenen_US
dc.contributor.authorLiang, Che-Changen_US
dc.contributor.authorLin, Yu-Chaoen_US
dc.contributor.authorMeng, Hsin-Feien_US
dc.contributor.authorZan, Hsiao-Wenen_US
dc.contributor.authorHorng, Sheng-Fuen_US
dc.contributor.authorLiou, Dann-Yingen_US
dc.contributor.authorCheng, Henrichen_US
dc.date.accessioned2015-12-02T02:59:27Z-
dc.date.available2015-12-02T02:59:27Z-
dc.date.issued2015-11-01en_US
dc.identifier.issn1566-1199en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.orgel.2015.07.040en_US
dc.identifier.urihttp://hdl.handle.net/11536/128220-
dc.description.abstractA tip-shaped zinc ion solid-state sensor is made by two parallel optical fibers embedded closely in a sensing hydrogel film. The film is made of poly(2-hydroxyethyl methacrylate) (poly HEMA) hydrogel mixed with the selective fluorescent probe meso-2,6-Dichlorophenyltripyrrinone (TPN-Cl-2) with weight ratio of 0.025 wt%. A 405 nm laser output is sent from one fiber and the 622 nm fluorescence of the doped hydrogel is collected by the second fiber. Each fiber diameter is 370 mu m (core is 300 mu m), whose sum is roughly the tip diameter. The 0.4 cm by 0.5 cm tip has real-time response for zinc ion concentration over 10(-6) M, with marginal signal for 10(-7) M. The tip is inserted inside an oyster and successfully detects the zinc ions, showing that the sensor works in complex body fluid and tolerates certain mechanical stress. To show the potential application for medicine, the sensing film is applied for primary neuronal cultures. We report for the first time zinc ions release at concentration levels 10(-6)-10(-7) M to the medium under stress conditions of ischemia, inflammation, and intoxication. Furthermore, this correlates with the zinc levels detected by biochemical assay. Such sensing tip has great potential for biomedical monitoring ex vivo or in vivo. (C) 2015 Elsevier B.V. All rights reserved.en_US
dc.language.isoen_USen_US
dc.subjectSolid-stateen_US
dc.subjectSensing tipen_US
dc.subjectZinc ionen_US
dc.subjectDouble fibersen_US
dc.subjectNeuronal culturesen_US
dc.titleSolid-state sensing tip for zinc ion with double parallel optical fibers embedded in fluorescent hydrogelen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.orgel.2015.07.040en_US
dc.identifier.journalORGANIC ELECTRONICSen_US
dc.citation.volume26en_US
dc.citation.spage429en_US
dc.citation.epage438en_US
dc.contributor.department分子醫學與生物工程研究所zh_TW
dc.contributor.department物理研究所zh_TW
dc.contributor.department光電工程學系zh_TW
dc.contributor.departmentInstitute of Molecular Medicine and Bioengineeringen_US
dc.contributor.departmentInstitute of Physicsen_US
dc.contributor.departmentDepartment of Photonicsen_US
dc.identifier.wosnumberWOS:000361226900065en_US
dc.citation.woscount0en_US
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