標題: High prevalence of fluoroquinolone-nonsusceptible Streptococcus pyogenes emm12 in Taiwan
作者: Lin, Jiun-Nong
Chang, Lin-Li
Lai, Chung-Hsu
Huang, Yi-Han
Chen, Wei-Fang
Yang, Chih-Hui
Hsu, Janine
Lin, Hsi-Hsun
Chen, Yen-Hsu
生醫工程研究所
Institute of Biomedical Engineering
關鍵字: Streptococcus pyogenes;Group A streptococcus;Fluoroquinolone resistance;Quinolone resistance-determining regions
公開日期: 1-Oct-2015
摘要: Fluoroquinolone-nonsusceptible Streptococcus pyogenes has rapidly emerged in several countries. The aim of this study was to survey the epidemiology and molecular characteristics of fluoroquinolone-nonsusceptible S. pyogenes in Taiwan. A total of 350 consecutive S. pyogenes isolates were collected between January 2005 and December 2012, including 152 (43.4%) invasive and 198 (56.6%) noninvasive isolates. Thirty-nine isolates (11.1%) of S. pyogenes were nonsusceptible to fluoroquinolones, including one emm1/ST28, 4 emm4/ST39, 33 emm12/ST36, and 1 emm87/5T62. Of all the isolates, emm12 (50%) demonstrated the highest prevalence of fluoroquinolone nonsusceptibility. Alterations of Ser79Phe and Ala12Val in ParC were the most frequently mutations in fluoroquinolone-nonsusceptible S. pyogenes isolates. There were no amino acid substitutions in GyrB, and 1 emm87 isolate exhibited 3 nonsynonymous mutations in ParE. Our study reveals the emergence of fluoroquinolone-nonsusceptible S. pyogenes emm12/ST36 in Taiwan. Regular surveillance of fluoroquinolone susceptibility in S. pyogenes is suggested. (C) 2015 Elsevier Inc. All rights reserved.
URI: http://dx.doi.org/10.1016/j.diagmicrobio.2015.06.018
http://hdl.handle.net/11536/128255
ISSN: 0732-8893
DOI: 10.1016/j.diagmicrobio.2015.06.018
期刊: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
Volume: 83
起始頁: 187
結束頁: 192
Appears in Collections:Articles