標題: Self-Monitoring and Self-Delivery of Photosensitizer-Doped Nanoparticles for Highly Effective Combination Cancer Therapy in Vitro and in Vivo
作者: Zhang, Jinfeng
Liang, Yu-Chuan
Lin, Xudong
Zhu, Xiaoyue
Yan, Li
Li, Shengliang
Yang, Xia
Zhu, Guangyu
Rogach, Andrey L.
Yu, Peter K. N.
Shi, Peng
Tu, Lung-Chen
Chang, Chia-Ching
Zhang, Xiaohong
Chen, Xianfeng
Zhang, Wenjun
Lee, Chun-Sing
生物科技學系
Department of Biological Science and Technology
關鍵字: self-monitoring;self-delivery;FRET;combination therapy;in vitro;in vivo
公開日期: 1-Oct-2015
摘要: Theranostic nanomedicine is capable of diagnosis, therapy, and monitoring the delivery and distribution of drug molecules and has received growing interest. Herein, a self-monitored and self-delivered photosensitizer-doped FRET nanoparticle (NP) drug delivery system (DDS) is designed for this purpose. During preparation, a donor/acceptor pair of perylene and 5,10,15,20-tetro (4-pyridyl) porphyrin (H2TPyP) is co-doped into a chemotherapeutic anticancer drug curcumin (Cur) matrix. In the system, Cur works as a chemotherapeutic agent. In the meantime, the green fluorescence of Cur molecules is quenched (OFF) in the form of NPs and can be subsequently recovered (ON) upon release in tumor cells, which enables additional imaging and real-time self-monitoring capabilities. H2TPyP is employed as a photodynamic therapeutic drug, but it also emits efficient NIR fluorescence for diagnosis via FRET from perylene. By exploiting the emission characteristics of these two emitters, the combinatorial drugs provide a real-time dual-fluorescent imaging/tracking system in vitro and in vivo, and this has not been reported before in self-delivered DDS which simultaneously shows a high drug loading capacity (77.6%cur). Overall, our carrier-free DDS is able to achieve chemotherapy (Cur), photodynamic therapy (H2TPyP), and real-time self-monitoring of the release and distribution of the nanomedicine (Cur and H2TPyP). More importantly, the as-prepared NPs show high cancer therapeutic efficiency both in vitro and in vivo. We expect that the present real-time self-monitored and self-delivered DDS with multiple-therapeutic and multiple-fluorescent ability will have broad applications in future cancer therapy.
URI: http://dx.doi.org/10.1021/acsnano.5b02513
http://hdl.handle.net/11536/128424
ISSN: 1936-0851
DOI: 10.1021/acsnano.5b02513
期刊: ACS NANO
Issue: 10
起始頁: 9741
結束頁: 9756
Appears in Collections:Articles