標題: | Skeletally Diverse Synthesis of Innovative [2,1-c]-1,4-Oxazepine and [1,4]-Quinoxaline Systems |
作者: | Lee, Chia-Hsin Wu, Wen-Chun Dangate, Prasad S. Shen, Li-Ching Chung, Wen-Sheng Sun, Chung-Ming 應用化學系 Department of Applied Chemistry |
關鍵字: | oxazepine;quinoxaline;pyrimido-pyrrolo motifs;unconventional Pictet-Spengler reaction strategy |
公開日期: | 1-十月-2015 |
摘要: | An efficient, innovative synthesis of [2,1-c]-1, 4-oxazepine and [1,4]-quinoxaline heterocycles along with the embodied pyrimido-pyrrolo motifs was established. Initially, the pyrrole ring was installed using microwave irradiation through an intramolecular base-catalyzed cyclization between acetyl bromomethyl pyrimidine dione and o-amino phenyl methanol or o-phenylenediamine methyl benzoates. Furthermore, oxazepine, and quinoxaline scaffolds were constructed by an acid-catalyzed condensation with a variety of aldehydes by an unconventional Pictet-Spengler reaction strategy. An important aspect of this work is to build novel heterocyclic ring systems with potential medicinal interest. |
URI: | http://dx.doi.org/10.1021/acscombsci.5b00093 http://hdl.handle.net/11536/128431 |
ISSN: | 2156-8952 |
DOI: | 10.1021/acscombsci.5b00093 |
期刊: | ACS COMBINATORIAL SCIENCE |
Volume: | 17 |
Issue: | 10 |
起始頁: | 623 |
結束頁: | 630 |
顯示於類別: | 期刊論文 |