標題: Skeletally Diverse Synthesis of Innovative [2,1-c]-1,4-Oxazepine and [1,4]-Quinoxaline Systems
作者: Lee, Chia-Hsin
Wu, Wen-Chun
Dangate, Prasad S.
Shen, Li-Ching
Chung, Wen-Sheng
Sun, Chung-Ming
應用化學系
Department of Applied Chemistry
關鍵字: oxazepine;quinoxaline;pyrimido-pyrrolo motifs;unconventional Pictet-Spengler reaction strategy
公開日期: 1-十月-2015
摘要: An efficient, innovative synthesis of [2,1-c]-1, 4-oxazepine and [1,4]-quinoxaline heterocycles along with the embodied pyrimido-pyrrolo motifs was established. Initially, the pyrrole ring was installed using microwave irradiation through an intramolecular base-catalyzed cyclization between acetyl bromomethyl pyrimidine dione and o-amino phenyl methanol or o-phenylenediamine methyl benzoates. Furthermore, oxazepine, and quinoxaline scaffolds were constructed by an acid-catalyzed condensation with a variety of aldehydes by an unconventional Pictet-Spengler reaction strategy. An important aspect of this work is to build novel heterocyclic ring systems with potential medicinal interest.
URI: http://dx.doi.org/10.1021/acscombsci.5b00093
http://hdl.handle.net/11536/128431
ISSN: 2156-8952
DOI: 10.1021/acscombsci.5b00093
期刊: ACS COMBINATORIAL SCIENCE
Volume: 17
Issue: 10
起始頁: 623
結束頁: 630
顯示於類別:期刊論文