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dc.contributor.authorCHANG Chia-Chingen_US
dc.contributor.authorCHEN Gong-Shenen_US
dc.contributor.authorCHENG Tsai-Muen_US
dc.contributor.authorCHU Hsueh-Liangen_US
dc.date.accessioned2015-12-04T07:03:10Z-
dc.date.available2015-12-04T07:03:10Z-
dc.date.issued2015-07-02en_US
dc.identifier.govdocA61K009/50zh_TW
dc.identifier.govdocA61K049/18zh_TW
dc.identifier.govdocA61K009/14zh_TW
dc.identifier.urihttp://hdl.handle.net/11536/128673-
dc.description.abstractThe present invention provides a method for preparing a reconstituted apolipoprotein B lipoparticle and the method comprises steps of (a) dissolving an apolipoprotein B and a lipid in a first buffer containing 2 M to 8 M urea and 1 wt % to 15 wt % amphiphilic compounds to form a mixture; and (b) dialyzing the mixture against a second buffer containing 0 M to 2M urea and 0 wt % to 0.5 wt % amphiphilic compounds for 1 to several times for lowering concentrations of the urea and the amphiphilic compounds in the mixture. The present invention further provides an apolipoprotein B lipoparticle and a use for the production of an apolipoprotein B lipoparticle used for delivering a hydrophobic substance.zh_TW
dc.language.isozh_TWen_US
dc.titleRECONSTITUTED APOLIPOPROTEIN B LIPOPARTICLE, A PREPARATION METHOD AND USES THEREOFzh_TW
dc.typePatentsen_US
dc.citation.patentcountryUSAzh_TW
dc.citation.patentnumber20150182470zh_TW
Appears in Collections:Patents


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