標題: Multicomponent Synthesis of Functionalized Tetrahydroacridinones: Insights into a Mechanistic Route
作者: Chung, Tsai-Wen
Narhe, Bharat D.
Lin, Chun-Cheng
Sun, Chung-Ming
應用化學系
Department of Applied Chemistry
公開日期: 6-Nov-2015
摘要: A mechanistic study of three-component reactions of various aromatic amines with a number of aldehydes and 1,3-diones was achieved. The unprecedented reaction involved a nucleophilic attack of an aromatic amine on the in situ generated Michael adduct intermediate followed by six-electron ring cyclizations. It is contrary to the common belief that advocates involvement of coupling reactions between a Knoevenagel adduct and an aromatic amine to deliver substituted tetrahydroacridinones.
URI: http://dx.doi.org/10.1021/acs.orglett.5b02705
http://hdl.handle.net/11536/129385
ISSN: 1523-7060
DOI: 10.1021/acs.orglett.5b02705
期刊: ORGANIC LETTERS
Volume: 17
Issue: 21
起始頁: 5368
結束頁: 5371
Appears in Collections:Articles