標題: Womb-on-a-chip biomimetic system for improved embryo culture and development
作者: Chang, Kuo-Wei
Chang, Pei-Yu
Huang, Hong-Yuan
Li, Chin-Jung
Tien, Chang-Hung
Yao, Da-Jeng
Fan, Shih-Kang
Hsu, Wensyang
Liu, Cheng-Hsien
機械工程學系
Department of Mechanical Engineering
關鍵字: Biomimetic microsystem;Embryo;Endometrial stromal cell;Embryonic development
公開日期: 1-四月-2016
摘要: The 3D biomimetic microsystem described in this research integrates various functions of the fallopian tube to serve as an in vitro platform for fertilization and embryonic development. This device mimics the in vivo embryo-endometrial stromal cell monolayer coculture to enhance the group culture of embryos and mechanically culture the embryos in a dynamic manner to enhance their development. The microdevice presented here is compared with static culture for embryonic development rate in the presence and absence of epithelial cells. The results suggest that the dynamic biomimetic microsystem enhances the rate of embryo development, providing a culture environment that closely mimics the in vivo microenvironment. This all-in-one biomimetic microsystem has the potential to replace the present embryo culture platforms used for assisting in vitro fertilization. (C) 2015 Elsevier B.V. All rights reserved.
URI: http://dx.doi.org/10.1016/j.snb.2015.11.004
http://hdl.handle.net/11536/129618
ISSN: 0925-4005
DOI: 10.1016/j.snb.2015.11.004
期刊: SENSORS AND ACTUATORS B-CHEMICAL
Volume: 226
起始頁: 218
結束頁: 226
顯示於類別:期刊論文