標題: Skeletally Diverse Synthesis of Indole-Fused Diazocine and Diazepine Frameworks by One-Pot, Two-Component Cascade Reaction
作者: Thikekar, Tushar Ulhas
Selvaraju, Manikandan
Sun, Chung-Ming
應用化學系
Department of Applied Chemistry
公開日期: 15-Jan-2016
摘要: An expeditious and novel strategy has been explored for the synthesis of structurally diverse indole-fused diazocine and diazepine derivatives. A substrate-based diversification approach of methyl-3-aminoindole/indoline benzoates coupled with the Pictet-Spengler reaction and three different reaction cascades furnished indolodiazepine and indoloquinoxalines. The formation of indolodiazocines proceeds through an initial condensation followed by intramolecular alkylation.
URI: http://dx.doi.org/10.1021/acs.orglett.5b03481
http://hdl.handle.net/11536/129669
ISSN: 1523-7060
DOI: 10.1021/acs.orglett.5b03481
期刊: ORGANIC LETTERS
Volume: 18
起始頁: 316
結束頁: 319
Appears in Collections:Articles