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dc.contributor.authorSelvaraju, Manikandanen_US
dc.contributor.authorDhole, Sandipen_US
dc.contributor.authorSun, Chung-Mingen_US
dc.date.accessioned2017-04-21T06:56:41Z-
dc.date.available2017-04-21T06:56:41Z-
dc.date.issued2016-10-07en_US
dc.identifier.issn0022-3263en_US
dc.identifier.urihttp://dx.doi.org/10.1021/acs.joc.6b01586en_US
dc.identifier.urihttp://hdl.handle.net/11536/132642-
dc.description.abstractA divergent reaction of 2-aminobenzimidazole with isothiocyanates and dihalomethanes has been developed for the selective synthesis of benzoimidazothiazetidine and benzoimidazothiadiazine. A single-pot reaction of 2-aminobenzimidazole in the presence of sodium hydride delivers benzoimidazothiazetidine, whereas triethylamine promotes the formation of benzoimidazothiadiazine via a sequential stepwise, fashion. The reaction sequence involves the initial formation of thiourea followed by regioselective nucleophilic addition and intramolecular ring-closing with dihalo electrophiles. The observed regioselectivity,of this reaction is governed by the nature of bases and the reaction sequence.en_US
dc.language.isoen_USen_US
dc.titleThree Component Divergent Reactions: Base-Controlled Amphiphilic Synthesis of Benzimidazole-Linked Thiazetidines and Fused Thiadiazinesen_US
dc.identifier.doi10.1021/acs.joc.6b01586en_US
dc.identifier.journalJOURNAL OF ORGANIC CHEMISTRYen_US
dc.citation.volume81en_US
dc.citation.issue19en_US
dc.citation.spage8867en_US
dc.citation.epage8875en_US
dc.contributor.department應用化學系zh_TW
dc.contributor.departmentDepartment of Applied Chemistryen_US
dc.identifier.wosnumberWOS:000385054300019en_US
Appears in Collections:Articles