Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Selvaraju, Manikandan | en_US |
dc.contributor.author | Dhole, Sandip | en_US |
dc.contributor.author | Sun, Chung-Ming | en_US |
dc.date.accessioned | 2017-04-21T06:56:41Z | - |
dc.date.available | 2017-04-21T06:56:41Z | - |
dc.date.issued | 2016-10-07 | en_US |
dc.identifier.issn | 0022-3263 | en_US |
dc.identifier.uri | http://dx.doi.org/10.1021/acs.joc.6b01586 | en_US |
dc.identifier.uri | http://hdl.handle.net/11536/132642 | - |
dc.description.abstract | A divergent reaction of 2-aminobenzimidazole with isothiocyanates and dihalomethanes has been developed for the selective synthesis of benzoimidazothiazetidine and benzoimidazothiadiazine. A single-pot reaction of 2-aminobenzimidazole in the presence of sodium hydride delivers benzoimidazothiazetidine, whereas triethylamine promotes the formation of benzoimidazothiadiazine via a sequential stepwise, fashion. The reaction sequence involves the initial formation of thiourea followed by regioselective nucleophilic addition and intramolecular ring-closing with dihalo electrophiles. The observed regioselectivity,of this reaction is governed by the nature of bases and the reaction sequence. | en_US |
dc.language.iso | en_US | en_US |
dc.title | Three Component Divergent Reactions: Base-Controlled Amphiphilic Synthesis of Benzimidazole-Linked Thiazetidines and Fused Thiadiazines | en_US |
dc.identifier.doi | 10.1021/acs.joc.6b01586 | en_US |
dc.identifier.journal | JOURNAL OF ORGANIC CHEMISTRY | en_US |
dc.citation.volume | 81 | en_US |
dc.citation.issue | 19 | en_US |
dc.citation.spage | 8867 | en_US |
dc.citation.epage | 8875 | en_US |
dc.contributor.department | 應用化學系 | zh_TW |
dc.contributor.department | Department of Applied Chemistry | en_US |
dc.identifier.wosnumber | WOS:000385054300019 | en_US |
Appears in Collections: | Articles |