標題: Nucleobase-Functionalized Supramolecular Micelles with Tunable Physical Properties for Efficient Controlled Drug Release
作者: Cheng, Chih-Chia
Lin, I-Hong
Chen, Jem-Kun
Liao, Zhi-Sheng
Huang, Jyun-Jie
Lee, Duu-Jong
Xin, Zhong
應用化學系
Department of Applied Chemistry
關鍵字: biocomplementary interaction;controlled-release drug delivery;pH-responsive micelle;self-assembly;supramolecular polymer
公開日期: Oct-2016
摘要: Complementary nucleobase-functionalized polymeric micelles, a combination of adenine-thymine (A-U) base pairs and a blend of hydrophilic-hydrophobic polymer pairs, can be used to construct 3D supramolecular polymer networks; these micelles exhibit excellent self-assembly ability in aqueous solution, rapid pH-responsiveness, high drug loading capacity, and triggerable drug release. In this study, a multi-uracil functionalized poly(epsilon-caprolactone) (U-PCL) and adenine end-capped difunctional oligomeric poly(ethylene glycol) (BA-PEG) are successfully developed and show high affinity and specific recognition in solution owing to dynamically reversible A-U-induced formation of physical cross-links. The U-PCL/BA-PEG blend system produces supramolecular micelles that can be readily adjusted to provide the desired critical micellization concentration, particle size, and stability. Importantly, in vitro release studies show that doxorubicin (DOX)-loaded micelles exhibit excellent DOX-encapsulated stability under physiological conditions. When the pH value of the solution is reduced from 7.4 to 5.0, DOX-loaded micelles can be rapidly triggered to release encapsulated DOX, suggesting these polymeric micelles represent promising candidate pH-responsive nanocarriers for controlled-release drug delivery and pharmaceutical applications.
URI: http://dx.doi.org/10.1002/mabi.201600189
http://hdl.handle.net/11536/132651
ISSN: 1616-5187
DOI: 10.1002/mabi.201600189
期刊: MACROMOLECULAR BIOSCIENCE
Volume: 16
Issue: 10
起始頁: 1415
結束頁: 1421
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