標題: Regioselective synthesis of imidazo[1,5-a]quinoxalines and methyl N-phenylbenzimidats on an ionic liquid support
作者: Chen, Li-Hsun
Kao, Chih-Hsien
Dhole, Sandip
Barve, Indrajeet J.
Shen, Li-Ching
Chung, Wen-Sheng
Sun, Chung-Ming
應用化學系
Department of Applied Chemistry
公開日期: 1-Jan-2016
摘要: An ionic liquid (IL) supported, regioselective synthesis of imidazo[1,5-a]quinoxalines and methyl N-phenylbenzimidats under microwave conditions was reported. The IL-immobilized aromatic amines were reacted with various ketones and aliphatic aldehydes using an unconventional Pictet-Spengler reaction to generate polycyclic imidazo[1,5-a]quinoxalines. Alternatively, aromatic aldehydes afforded auto-oxidized imidazo[1,5-a]quinoxalines first which further converted to novel methyl N-phenylbenzimidats unexpectedly during the cleavage of the IL-support. In the reported strategy, rapidness is achieved through microwave conditions while the IL-support assists purification by simple precipitation.
URI: http://dx.doi.org/10.1039/c6ra11861e
http://hdl.handle.net/11536/132709
ISSN: 2046-2069
DOI: 10.1039/c6ra11861e
期刊: RSC ADVANCES
Volume: 6
Issue: 80
起始頁: 0
結束頁: 0
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