標題: Two-Photon Photoexcited Photodynamic Therapy and Contrast Agent with Antimicrobial Graphene Quantum Dots
作者: Kuo, Wen-Shun
Chang, Chia-Yuan
Chen, Hua-Han
Hsu, Chih-Li Lilian
Wang, Jiu-Yao
Kao, Hui-Fang
Chou, Lawrence Chao-Shan
Chen, Yi-Chun
Chen, Shean-Jen
Chang, Wen-Tsan
Tseng, Shih-Wen
Wu, Ping-Ching
Pu, Ying-Chih
光電學院
College of Photonics
關鍵字: graphene quantum dot;two-photon photodynamic therapy;reactive oxygen species;three-dimensional two photon bioimaging;multidrug resistant
公開日期: 9-Nov-2016
摘要: A graphene quantum dot (GQD) used as the photosensitizer with high two-photon absorption in the near-infrared region, a large absolute cross section of two-photon excitation (TPE), strong two-photon luminescence, and impressive two-photon stability could be used for dual modality two-photon photodynamic therapy (PDT) and two-photon bioimaging with an ultrashot pulse laser (or defined as TPE). In this study, a GQD efficiently generated reactive oxygen species coupled with TPE, which highly increased the effective PDT ability of both Gram-positive and-negative bacteria, with ultralow energy and an extremely short photoexcitation time generated by TPE. Because of its two-photon properties, a GQD could serve,as a promising two photon contrast agent for observing specimens in depth in three-din-tensional biological environments while simultaneously proceeding with PDT action to eliminate bacteria, particularly in multidrug-resistant (MDR) strains. This procedure would provide an efficient alternative approach to easily cope with MDR bacteria.
URI: http://dx.doi.org/10.1021/acsami.6b12014
http://hdl.handle.net/11536/132818
ISSN: 1944-8244
DOI: 10.1021/acsami.6b12014
期刊: ACS APPLIED MATERIALS & INTERFACES
Volume: 8
Issue: 44
起始頁: 30467
結束頁: 30474
Appears in Collections:Articles