標題: An enzymatic approach to configurationally rare trans-androsteronyl--glucoside and Its potential anticancerapplication
作者: Chou, Feng-Pai
Tsai, Chia-Tse
Chiou, Ya-Sheng
Chen, Yi-Ju
Li, Meng-Erh
Guo, Ting-Wei
Lyu, Jason WenJay
Chou, Sheng-Hao
Wu, Tung-Kung
生物科技學系
Department of Biological Science and Technology
關鍵字: glycosyltransferase;Helicobacter pylori;MCF-7 breast cancer cell;steroid -glucoside;sterol
公開日期: Jan-2017
摘要: Enzymatic glycosylation of sterols/steroids with glycosyltransferase HP0421 shows protein plasticity on generation of configurationally rare steryl--glucosides. Investigation of trans-androsteronyl--glucoside on tamoxifen-treated MCF-7 breast cancer cells shows dose-dependent depression of cell viability and enhanced drug effectiveness, illustrating a new avenue for the production of novel steryl--glucosides with useful biological activities.
URI: http://dx.doi.org/10.1111/cbdd.12830
http://hdl.handle.net/11536/132958
ISSN: 1747-0277
DOI: 10.1111/cbdd.12830
期刊: CHEMICAL BIOLOGY & DRUG DESIGN
Volume: 89
Issue: 1
起始頁: 61
結束頁: 66
Appears in Collections:Articles