標題: Glucocorticoids may compromise the effect of gefitinib in non-small cell lung cancer
作者: Wang, Hsian-Yu
Chang, Yu-Ling
Cheng, Chun-Chun
Chao, Min-Wu
Lin, Su-I
Pan, Shiow-Lin
Hsu, Chih-Cheng
Liu, Tsang-Wu
Cheng, Han-Chin
Tseng, Ching-Ping
Liu, Shih-Jen
Tsai, Hui-Ju
Chang, Hsing-Yi
Hsu, John T. -A.
生物資訊及系統生物研究所
分子醫學與生物工程研究所
Institude of Bioinformatics and Systems Biology
Institute of Molecular Medicine and Bioengineering
關鍵字: NSCLC;EGFR;TKI;glucocorticoids;national health insurance research database taiwan
公開日期: 27-Dec-2016
摘要: The epidermal growth factor receptor (EGFR)-targeting tyrosine kinase inhibitors (TKIs) have shown remarkable benefits in non-small cell lung cancer (NSCLC) patients with drug-sensitive mutations in the EGFR gene. Responsive patients are usually continuously prescribed with TKIs until disease progression. Glucocorticoids (GCs) are potent homeostasis maintaining drugs and are frequently used in cancer patients to alleviate discomforts caused by anti-cancer therapies. Several previous studies reported that concomitant use of GCs may compromise the efficacy of chemo-therapeutics in patients with solid tumors. Little is known in the concomitant use of target therapy with GCs in treating NSCLC. In this study, we hypothesized that concomitant use of GCs in EGFR-TKI therapy may be detrimental and addressed this issue using cell cultures and xenograft studies followed by a retrospective population study based on data from the Taiwan national health insurance system. In cell cultures and xenograft studies, GCs were shown to unequally compromise the anti-cancer efficacy of TKIs in both PC9 and NCI-H1975 NSCLC cells models. In the retrospective population study, patients with similar disease status that were co-medicated with GCs had a significantly higher risk of disease progression.
URI: http://dx.doi.org/10.18632/oncotarget.13185
http://hdl.handle.net/11536/133073
ISSN: 1949-2553
DOI: 10.18632/oncotarget.13185
期刊: ONCOTARGET
Volume: 7
Issue: 52
起始頁: 85917
結束頁: 85928
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