標題: | miRTarBase 2016: updates to the experimentally validated miRNA-target interactions database |
作者: | Chou, Chih-Hung Chang, Nai-Wen Shrestha, Sirjana Hsu, Sheng-Da Lin, Yu-Ling Lee, Wei-Hsiang Yang, Chi-Dung Hong, Hsiao-Chin Wei, Ting-Yen Tu, Siang-Jyun Tsai, Tzi-Ren Ho, Shu-Yi Jian, Ting-Yan Wu, Hsin-Yi Chen, Pin-Rong Lin, Nai-Chieh Huang, Hsin-Tzu Yang, Tzu-Ling Pai, Chung-Yuan Tai, Chun-San Chen, Wen-Liang Huang, Chia-Yen Liu, Chun-Chi Weng, Shun-Long Liao, Kuang-Wen Hsu, Wen-Lian Huang, Hsien-Da 交大名義發表 生物科技學系 生物資訊及系統生物研究所 分子醫學與生物工程研究所 生物資訊研究中心 National Chiao Tung University Department of Biological Science and Technology Institude of Bioinformatics and Systems Biology Institute of Molecular Medicine and Bioengineering Center for Bioinformatics Research |
公開日期: | 4-Jan-2016 |
摘要: | MicroRNAs (miRNAs) are small non-coding RNAs of approximately 22 nucleotides, which negatively regulate the gene expression at the post-transcriptional level. This study describes an update of the miRTarBase (http://miRTarBase.mbc.nctu.edu.tw/) that provides information about experimentally validated miRNA-target interactions (MTIs). The latest update of the miRTarBase expanded it to identify systematically Argonaute-miRNA-RNA interactions from 138 crosslinking and immunoprecipitation sequencing (CLIP-seq) data sets that were generated by 21 independent studies. The database contains 4966 articles, 7439 strongly validated MTIs (using reporter assays or western blots) and 348 007 MTIs from CLIP-seq. The number of MTIs in the miRTarBase has increased around 7-fold since the 2014 miRTarBase update. The miRNA and gene expression profiles from The Cancer Genome Atlas (TCGA) are integrated to provide an effective overview of this exponential growth in the miRNA experimental data. These improvements make the miRTarBase one of the more comprehensively annotated, experimentally validated miRNA-target interactions databases and motivate additional miRNA research efforts. |
URI: | http://dx.doi.org/10.1093/nar/gkv1258 http://hdl.handle.net/11536/133085 |
ISSN: | 0305-1048 |
DOI: | 10.1093/nar/gkv1258 |
期刊: | NUCLEIC ACIDS RESEARCH |
Volume: | 44 |
Issue: | D1 |
起始頁: | 0 |
結束頁: | 0 |
Appears in Collections: | Articles |
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