標題: | A heuristic approach for detecting RNA H-type pseudoknots |
作者: | Huang, CH Lu, CL Chiu, HT 生物科技學系 Department of Biological Science and Technology |
公開日期: | 1-Sep-2005 |
摘要: | Motivation: RNA H-type pseudoknots are ubiquitous pseudoknots that are found in almost all classes of RNA and thought to play very important roles in a variety of biological processes. Detection of these RNA H-type pseudoknots can improve our understanding of RNA structures and their associated functions. However, the currently existing programs for detecting such RNA H-type pseudoknots are still time consuming and sometimes even ineffective. Therefore, efficient and effective tools for detecting the RNA H-type pseudoknots are needed. Results: In this paper, we have adopted a heuristic approach to develop a novel tool, called HPknotter, for efficiently and accurately detecting H-type pseudoknots in an RNA sequence. In addition, we have demonstrated the applicability and effectiveness of HPknotter by testing on some sequences with known H-type pseudoknots. Our approach can be easily extended and applied to other classes of more general pseudoknots. |
URI: | http://dx.doi.org/10.1093/bioinformatics/bti568 http://hdl.handle.net/11536/13331 |
ISSN: | 1367-4803 |
DOI: | 10.1093/bioinformatics/bti568 |
期刊: | BIOINFORMATICS |
Volume: | 21 |
Issue: | 17 |
起始頁: | 3501 |
結束頁: | 3508 |
Appears in Collections: | Articles |
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