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dc.contributor.authorCheng, Chih-Chiaen_US
dc.contributor.authorChang, Feng-Chihen_US
dc.contributor.authorKao, Wan-Yien_US
dc.contributor.authorHwang, Shiaw-Minen_US
dc.contributor.authorLiao, Li-Chuanen_US
dc.contributor.authorChang, Yu-Jenen_US
dc.contributor.authorLiang, Mei-Chihen_US
dc.contributor.authorChen, Jem-Kunen_US
dc.contributor.authorLee, Duu-Jongen_US
dc.date.accessioned2017-04-21T06:56:50Z-
dc.date.available2017-04-21T06:56:50Z-
dc.date.issued2016-03-15en_US
dc.identifier.issn1742-7061en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.actbio.2016.01.018en_US
dc.identifier.urihttp://hdl.handle.net/11536/133475-
dc.description.abstractThe novel concept of modifying and enhancing the properties of existing functional micelles through self-complementary interactions has significant potential. In this study, a practical approach to living polymerization of functionalized thermoresponsive monomers enabled the incorporation of self constituted multiple hydrogen bonded groups into micelles that have potential as supramolecular drug-delivery systems. Phase transitions and morphological studies in aqueous solution showed that the microstructure can be controlled to achieve well-defined vesicle-like micelles with respect to the strength of the hydrogen bond segment. Thus, the resulting micelles have a very low critical micellization concentration and very high loading capacity (16.1%), making the loading process extremely stable and efficient. Incorporation of the anticancer drug doxorubicin (DOX) affected the micellization process in aqueous solution and enabled fine-tuning of drug loading and precise control of drug release rate with excellent sensitivity. Release studies in vitro showed that DOX-loaded micelles exerted dose dependent cytotoxicity against human liver carcinoma (HepG2) cells at the physiological temperature of 37 degrees C. In addition, DOX-loaded micelles were efficiently endocytosed by the cancer cells, which may enable the micelles to serve as suitable vehicles for effective delivery of anticancer drugs to primary tumors and metastatic disease. This newly developed material may provide a potential route towards next-generation drug delivery vehicles. Statement of Significance A breakthrough innovation in water-based thermo-responsive polymers has enabled significant progress in developing smart stimuli-responsive nanocarriers by generating novel "supramolecular polymeric micelles" via self-complementary hydrogen-bonding interactions. These newly developed micelles exhibit extremely high micellar stability and drug loading capacity (up to 16%), excellent thermo-responsive behavior and precise control of drug release rate due to hydrogen-bond-induced physical cross-linking. In addition, doxorubicin-loaded micelles were efficiently endocytosed by the cancer cells, which allows them to serve as suitable vehicles for effective delivery of anticancer drugs to primary tumors and metastatic disease. Thus, this work provides a potential route for the development of next generation multifunctional nanocarriers that have improved safety and to increase the therapeutic efficacy of anticancer therapy. (C) 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.en_US
dc.language.isoen_USen_US
dc.subjectDrug deliveryen_US
dc.subjectMultiple hydrogen bondsen_US
dc.subjectSelf-assemblyen_US
dc.subjectSupramolecular micellesen_US
dc.subjectThermoresponsive polymersen_US
dc.titleHighly efficient drug delivery systems based on functional supramolecular polymers: In vitro evaluationen_US
dc.identifier.doi10.1016/j.actbio.2016.01.018en_US
dc.identifier.journalACTA BIOMATERIALIAen_US
dc.citation.volume33en_US
dc.citation.spage194en_US
dc.citation.epage202en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.department應用化學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.contributor.departmentDepartment of Applied Chemistryen_US
dc.identifier.wosnumberWOS:000372688700019en_US
Appears in Collections:Articles