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dc.contributor.authorHe, Jinpingen_US
dc.contributor.authorWang, Nanen_US
dc.contributor.authorTsurui, Hiromichien_US
dc.contributor.authorKato, Masashien_US
dc.contributor.authorIida, Machikoen_US
dc.contributor.authorKobayashi, Takayoshien_US
dc.date.accessioned2019-04-03T06:40:16Z-
dc.date.available2019-04-03T06:40:16Z-
dc.date.issued2016-07-22en_US
dc.identifier.issn2045-2322en_US
dc.identifier.urihttp://dx.doi.org/10.1038/srep30209en_US
dc.identifier.urihttp://hdl.handle.net/11536/134018-
dc.description.abstractSkin cancer is one of the most common cancers. Melanoma accounts for less than 2% of skin cancer cases but causes a large majority of skin cancer deaths. Early detection of malignant melanoma remains the key factor in saving lives. However, the melanoma diagnosis is still clinically challenging. Here, we developed a confocal photothermal microscope for noninvasive, label-free, three-dimensional imaging of melanoma. The axial resolution of confocal photothermal microscope is similar to 3 times higher than that of commonly used photothermal microscope. Three-dimensional microscopic distribution of melanin in pigmented lesions of mouse skin is obtained directly with this setup. Classic morphometric and fractal analysis of sixteen 3D images (eight for benign melanoma and eight for malignant) showed a capability of pathology of melanoma: melanin density and size become larger during the melanoma growth, and the melanin distribution also becomes more chaotic and unregulated. The results suggested new options for monitoring the melanoma growth and also for the melanoma diagnosis.en_US
dc.language.isoen_USen_US
dc.titleNoninvasive, label-free, three-dimensional imaging of melanoma with confocal photothermal microscopy: Differentiate malignant melanoma from benign tumor tissueen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/srep30209en_US
dc.identifier.journalSCIENTIFIC REPORTSen_US
dc.citation.volume6en_US
dc.citation.spage0en_US
dc.citation.epage0en_US
dc.contributor.department電子物理學系zh_TW
dc.contributor.departmentDepartment of Electrophysicsen_US
dc.identifier.wosnumberWOS:000380202300001en_US
dc.citation.woscount4en_US
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