標題: Prophylactic acetylsalicylic acid attenuates the inflammatory response but fails to protect exercise-induced liver damage in exercised rats
作者: Huang, Kuo-Chin
Chiu, Yi-Han
Liao, Kuang-Wen
Ke, Chun-Yen
Lee, Chung-Jen
Chao, Yann-Fen C.
Lee, Ru-Ping
生物科技學系
Department of Biological Science and Technology
關鍵字: Nonsteroidal antiinflammatory drug;Aspirin;Exhaustion exercise;Liver injury
公開日期: 5-Sep-2016
摘要: This study evaluated the effects of acetylsalicylic acid (ASA) on exercise-induced inflammatory response, muscle damage, and liver injury in rats. Wistar-Kyoto (WKY) rats were divided into six groups: control (C), exercise (E), C+20 mg ASA, E+20 mg ASA, C+100 mg/kg ASA, and E+100 mg ASA groups. ASA or a vehicle was orally administered through gavage 1 h before a treadmill test. Upon trial completion, blood was drawn at 1, 12, and 24 h for biochemical analysis, and livers were excised at 24 h for a histological assessment. Our results revealed that 100 mg/kg ASA significantly reduced interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha levels in the E groups; however, the IL-10 level was considerably increased. Moreover, aspartate aminotransferase (AST), alanine aminotransferase (ALT) levels and histological hepatic damage increased significantly in the E+100 mg ASA group compared with the corresponding changes in the E group. These results suggest that the prophylactic administration of particularly high dose ASA alleviates exercise-induced inflammatory response but exacerbates liver injury. (C) 2016 Elsevier B.V. All rights reserved.
URI: http://dx.doi.org/10.1016/j.ejphar.2016.05.043
http://hdl.handle.net/11536/134061
ISSN: 0014-2999
DOI: 10.1016/j.ejphar.2016.05.043
期刊: EUROPEAN JOURNAL OF PHARMACOLOGY
Volume: 786
起始頁: 204
結束頁: 211
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