標題: Direct Detection of Long, Periodic, ssDNA nanostructures Assembled on CMOS Transistor Arrays
作者: Lin, Ming-Yu
Chang, Sheng-Ren
Kao, Jiann-Shiun
Chen, Hsin
Yang, Yuh-Shyong
生物科技學系
Department of Biological Science and Technology
公開日期: 2009
摘要: DNA is a wonderful material for the construction of nanostructures for a variety of applications. This paper describes a novel platform integrating single-stranded DNA (ssDNA) nanotemplates with CMOS-compatible, field-effect sensors. The field-effect sensor was based on oxide-semiconductor field-effect transistors (OSFETs), which were monolithically-integrated with signal-processing circuits to enhance the signal-to-noise ratio, and to detect the construction of ssDNA nanotemplate from complex DNA-protein interactions. The ssDNA nanotemplate on the transistor arrays was prepared by isothermal rolling circle amplification (RCA) through DNA aptamer-protein recognition and self-assembly strategy. The growth of the DNA nanostructure was monitored in situ, real-time and label-free on OSFET.
URI: http://dx.doi.org/10.1109/ICSENS.2009.5398146
http://hdl.handle.net/11536/134953
ISBN: 978-1-4244-4548-6
DOI: 10.1109/ICSENS.2009.5398146
期刊: 2009 IEEE SENSORS, VOLS 1-3
起始頁: 334
結束頁: +
Appears in Collections:Conferences Paper