標題: | Microwave-assisted benzimidazole cyclization by bismuth chloride |
作者: | Su, YS Sun, CM 應用化學系 Department of Applied Chemistry |
關鍵字: | bismuth chloride;combinatorial chemistry;liquid-phase method;microwave assisted synthesis;scaffold |
公開日期: | 17-五月-2005 |
摘要: | We have developed a multi-step, microwave-assisted method for the bismuth chloride catalyzed synthesis of 1,2-disubstituted benzimidazoles. Biologically interesting benzimidazoles were readily assembled using a SNAr reaction, reduction, and finally a bismuth(III)-mediated cyclization under microwave irradiation. The desired products were then liberated from the soluble matrix in excellent yield and purity after cleavage. Each step of the synthetic sequence was performed under microwave conditions. |
URI: | http://dx.doi.org/10.1055/s-2005-865240 http://hdl.handle.net/11536/13706 |
ISSN: | 0936-5214 |
DOI: | 10.1055/s-2005-865240 |
期刊: | SYNLETT |
Volume: | |
Issue: | 8 |
起始頁: | 1243 |
結束頁: | 1246 |
顯示於類別: | 期刊論文 |