標題: Surface characteristics and hemocompatibility of PAN/PVDF blend membranes
作者: Liu, TY
Lin, WC
Huang, LY
Chen, SY
Yang, MC
材料科學與工程學系
Department of Materials Science and Engineering
關鍵字: polyacrylonitrile;polyvinylidine fluoride;blends;miscibility;membranes
公開日期: 1-May-2005
摘要: Polyacrylonitrile (PAN) was blended with polyvinylidine fluoride (PVDF) at various ratios and made into membranes. The hemocompatibility of the resulting membranes was evaluated based on human plasma proteins adsorption, platelet adhesion, thrombus formation, and blood coagulation time. The PAN/PVDF blends exhibited partial miscibility according to the inward shifting of their two glass transition temperatures. The microstructures of blend membranes examined using atomic force microscopy (AFM) indicated that the roughness increased with the PVDF content, and the phase separation was too severe to form a membrane when the PVDF content was more than 30%. The water contact angle of PAN/PVDF blend membranes increased with the PVDF content. By blending with 20wt% apolar PVDF the adsorption of blood proteins could be reduced, and hence the platelet adhesion and thrombus formation was also reduced. However, when the PVDF content was 30 wt%, severe thrombogenicity was observed due probably to the more porous structure of blend membrane. These results demonstrated that the hemocompatibility would be improved for PAN/PVDF blend membranes with appropriate hydrophilicity and roughness. Copyright (c) 2005 John Wiley & Sons, Ltd.
URI: http://dx.doi.org/10.1002/pat.592
http://hdl.handle.net/11536/13772
ISSN: 1042-7147
DOI: 10.1002/pat.592
期刊: POLYMERS FOR ADVANCED TECHNOLOGIES
Volume: 16
Issue: 5
起始頁: 413
結束頁: 419
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