标题: | Distribution and susceptibility to amphotericin B and fluconazole of Candida spp. isolated from Taiwan |
作者: | Yang, YL Ho, YA Cheng, HH Lo, HJ 生物科技学系 Department of Biological Science and Technology |
公开日期: | 1-四月-2005 |
摘要: | Susceptibilities to amphotericin B and fluconazole of 628 clinical yeast strains collected from 22 hospitals in Taiwan were determined. A total of 53 isolates (8.4%) were resistant to fluconazole. Each hospital had different resistance rate to fluconazole ranging from 0 % to 24 %. None of the 186 isolates from eight of the 22 hospitals was resistant to fluconazole. In contrast, isolates from nine of the remaining 14 hospitals had greater than 10 % resistance rate to fluconazole. Consistently, 88.9 % (8/9) fluconazole-resistant C. albicans isolates were from hospitals having a high resistance rate to fluconazole. The prevalence of various Candida spp. in each hospital was different. A positive association was found between the prevalence of C. tropicalis and the resistance rate to fluconazole for individual hospitals. Although only three isolates (0.5 %) were resistant to amphotericin B, a co-resistance to both amphotericin B and fluconazole was observed, which highlights the emerging problem of drug resistance. |
URI: | http://dx.doi.org/10.1017/S0950268804003310 http://hdl.handle.net/11536/13875 |
ISSN: | 0950-2688 |
DOI: | 10.1017/S0950268804003310 |
期刊: | EPIDEMIOLOGY AND INFECTION |
Volume: | 133 |
Issue: | 2 |
起始页: | 325 |
结束页: | 330 |
显示于类别: | Articles |
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