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dc.contributor.author彭柏凱zh_TW
dc.contributor.author吳彥谷zh_TW
dc.contributor.author夏克山zh_TW
dc.contributor.authorPeng, Po-Kaien_US
dc.contributor.authorWu, Yen-Kuen_US
dc.contributor.authorShia, Kak-Shanen_US
dc.date.accessioned2018-01-24T07:41:59Z-
dc.date.available2018-01-24T07:41:59Z-
dc.date.issued2017en_US
dc.identifier.urihttp://etd.lib.nctu.edu.tw/cdrfb3/record/nctu/#GT070452570en_US
dc.identifier.urihttp://hdl.handle.net/11536/142276-
dc.description.abstract本篇研究共分為兩個章節: 第一章是研究在溫度控制的條件下利用硫化試劑合成出三取代之2-aminothiophene,此化合物可經加溫進一步硫化合環得到thieno[2,3-c]isothiazole。並探討其硫化反應的機制以及最佳化;亦利用thieno[2,3-c]isothiazole為骨架進一步修飾成具潛在IDO1抑制劑及其衍生物 23a-d;總反應途徑的步驟為 7 步,總產率為 5.6-9.5%。 第二章是探討利用本實驗室開發之自由基連鎖合環反應建立出具有發光性質之苯基[b]芴(benzo[b]fluorene)及其衍生物的合成,並嘗試利用此反應及官能基之修飾建立出具有不同螢光顏色之化合物 50d,以探討其作為新一代有機發光材料的價值。zh_TW
dc.description.abstractThis dissertation is divided into two parts: Chapter I describes that using a thiolating reagent by temperature control synthesize 2-aminothiophene and thieno[2,3-c]isothiazole selectivity. And explore this reaction mechanism and its optimization. Finally, The synthesis of analog of IDO1 inhibitor 23a-d by using this thiolation via 7 steps in an overall yield of 5.9-9.5%. Chapter II describes that benzo[b]fluorene and its derivative with luminescent properties was constructed by radical cascade cyclization has been developed. It was tried to establish the compound 50d compared the modification of functional groups with different fluorescent colors to explore its value as a new generation of organic luminescent materials.en_US
dc.language.isozh_TWen_US
dc.subject噻吩并[2,3-c]異噻唑zh_TW
dc.subjectIDO1抑制劑zh_TW
dc.subject苯並[b]芴zh_TW
dc.subjectthieno[2,3-c]isothiazoleen_US
dc.subjectIDO1 inhibitoren_US
dc.subjectbenzo[b]fluoreneen_US
dc.title(I) 以新穎反應開發具噻吩并異噻唑骨架 之分子及其衍生物之合成 與IDO1抑制劑的開發 及 (II) 以自由基連鎖合環反應建立具螢光性質 之苯基[b]芴衍生物之合成zh_TW
dc.title(I) Studies on the Synthesis of thieno[2,3-c]isothiazole anolog via novel reaction and development of IDO1 inhibitor and (II) Studies on the Synthesis of benzo[b]fluorene anolog with fluorescent property via radical cascade reactionen_US
dc.typeThesisen_US
dc.contributor.department應用化學系碩博士班zh_TW
Appears in Collections:Thesis