標題: Enantiospecific Synthesis of Imidazoquinazolin-2-ones via Base-Catalyzed Tandem Cyclization
作者: Kumar, Sunil
Ho, Pei-Heng
Barve, Indrajeet J.
Sun, Chung-Ming
應用化學系
Department of Applied Chemistry
關鍵字: Enantiospecific synthesis;imidazoquinazolines;intramolecular aminolysis;quinazolines;tandem protocol
公開日期: 29-Sep-2017
摘要: A facile protocol for the enantiospecific synthesis of novel (S)-3-substituted imidazo[2,l-b]quinazoline-2-ones via tandem reaction of substituted (S)-3-amino-4-aminomethylbenzoates and cyanogen bromide under basic conditions is explored. This tandem process involves addition reaction of substituted (S)-3-amino-4-aminomethylbenzoates to CNBr to yield 2-imino tetrahydroquinazoline carboxylate intermediates followed by insitu intramolecular aminolysis to afford the triheterocyclic imidazo[2,l-b]quinazoline-2-ones in good yields and high enantiomeric purity.
URI: http://dx.doi.org/10.1002/slct.201701686
http://hdl.handle.net/11536/143906
ISSN: 2365-6549
DOI: 10.1002/slct.201701686
期刊: CHEMISTRYSELECT
Volume: 2
起始頁: 8917
結束頁: 8921
Appears in Collections:Articles