標題: The role of indoxyl sulfate in renal anemia in patients with chronic kidney disease
作者: Wu, Chih-Jen
Chen, Cheng-Yi
Lai, Thung-S.
Wu, Pei-Chen
Chuang, Chih-Kuang
Sun, Fang-Ju
Liu, Hsuan-Liang
Chen, Han-Hsiang
Yeh, Hung-I.
Lin, Chih-Sheng
Lin, Cheng-Jui
生物科技學系
Department of Biological Science and Technology
關鍵字: indoxyl sulfate;chronic kidney disease;erythropoietin;renal anemia
公開日期: 10-Oct-2017
摘要: Renal anemia is a common complication in patients with advanced chronic kidney disease. In vitro studies have shown that indoxyl sulfate decreases erythropoietin production. Whether this effect is seen in vivo remains unclear. Our goal was to explore the role of indoxyl sulfate in renal anemia. We found serum indoxyl sulfate levels are significantly and negatively associated with erythropoietin levels in human. A multiple stepwise linear regression analyses after adjustment for other independent parameters revealed that free indoxyl sulfate, and total indoxyl sulfate were significantly associated with erythropoietin levels. In animal studies, erythropoietin gene and protein expression were markedly inhibited in rats with chronic kidney disease; however, this effect was significantly reversed by lowering serum indoxyl sulfate with AST-120. Indoxyl sulfate may also inhibit erythropoietin expression in animal models with chronic kidney disease. These findings further support the role of indoxyl sulfate in the development of renal anemia.
URI: http://dx.doi.org/10.18632/oncotarget.18789
http://hdl.handle.net/11536/143907
ISSN: 1949-2553
DOI: 10.18632/oncotarget.18789
期刊: ONCOTARGET
Volume: 8
起始頁: 83030
結束頁: 83037
Appears in Collections:Articles