Palladium-Catalyzed Regio- and Stereoselective Hydrosulfonation of Propiolate Esters

Abstract

An efficient palladium-catalyzed addition reaction of alkyland arylsulfonic acids to propiolate esters to yield alkenyl sulfonates is demonstrated. The formation of alkenyl sulfonates is highly regio- and stereoselective with favorable yields of up to 95%, and two of the alkenyl sulfonates are utilized for a Sonogashira cross-coupling reaction to produce (Z)-1,3-enynoates.