標題: | Risk of psychiatric disorders in Guillain-Barre syndrome: A nationwide, population-based, cohort study |
作者: | Tzeng, Nian-Sheng Chang, Hsin-An Chung, Chi-Hsiang Lin, Fu-Huang Yeh, Chin-Bin Huang, San-Yuan Chang, Chuan-Chia Lu, Ru-Band Kao, Yu-Chen Yeh, Hui-Wen Chiang, Wei-Shan Chien, Wu-Chien 生物資訊及系統生物研究所 Institude of Bioinformatics and Systems Biology |
關鍵字: | Guillain-Barre syndrome;Psychiatric disorders;Dementia Depressive disorder;Sleep disorder;Psychotic disorder;National Health Insurance Research Database;Cohort study |
公開日期: | 15-十月-2017 |
摘要: | Background Guillain-Barre syndrome (GBS) is a rare immune-related neurological disorder with high mortality and morbidity, but the comorbid psychiatric disorders garnered little attention in the GBS patients. This study aimed to investigate the association between GBS and the risk of developing psychiatric disorders. Methods: A total of 18,192 enrolled patients, with 4548 study subjects who had suffered GBS, and 13,644 controls matched for gender and age, from the Inpatient Dataset of 2000-2013 in Taiwan, and selected from the National Health Insurance Research Database (NHIRD). After adjusting for confounding factors, Cox proportional hazards analysis was used to compare the risk of developing psychiatric disorders during the 13 years of follow-up. Results: Of the study subjects, 471 (10.35%) developed psychiatric disorders when compared to 1023 (7.50%) in the control group. Fine and Gray's competing risk model analysis revealed that the study subjects were more likely to develop psychiatric disorders (crude hazard ratio [HR]: 4.281 (95% CI = 3.819-4.798, p < 0.001). After adjusting for gender, age, monthly income, urbanization level, geographic region, and comorbidities, the adjusted HR was 4.320 (95% CI = 3.852-4.842, p < 0.001). Dementia, depressive disorders, sleep disorders, and psychotic disorders predominate in these psychiatric disorders. Mechanical ventilation and hemodialysis are associated with a lower risk of dementia when compared to the control groups. Conclusions: Patients who suffered from GBS had a higher risk of developing psychiatric disorders, and this finding should act as a reminder to the clinicians that a regular psychiatric follow-up might well be needed for those patients. |
URI: | http://dx.doi.org/10.1016/j.jns.2017.08.022 http://hdl.handle.net/11536/144052 |
ISSN: | 0022-510X |
DOI: | 10.1016/j.jns.2017.08.022 |
期刊: | JOURNAL OF THE NEUROLOGICAL SCIENCES |
Volume: | 381 |
起始頁: | 88 |
結束頁: | 94 |
顯示於類別: | 期刊論文 |