標題: Organic Gas Sensor with an Improved Lifetime for Detecting Breath Ammonia in Hemodialysis Patients
作者: Chuang, Ming-Yen
Chen, Chang-Chiang
Zan, Hsiao-Wen
Meng, Hsin-Fei
Lu, Chia-Jung
生物科技學系
光電工程學系
Department of Biological Science and Technology
Department of Photonics
關鍵字: gas sensor;ammonia;organic;lifetime;breath;hemodialysis
公開日期: 1-Dec-2017
摘要: In this work, a TFB (poly[(9,9-dioctylfluorenyl-2,7-diyl)-co-(4,4'-(N-(4-s-butylphenyl)diphenylamine)]) sensor with a cylindrical nanopore structure exhibits a high sensitivity to ammonia in ppb-regime. The lifetime and sensitivity of the TFB sensor were studied and compared to those of P3HT (poly(3-hexylthiophene)), NPB (N,N'-di(1-naphthyl)-N,N'-diphenyl-(1,1'-biphenyl)-4,4'-diamine), and TAPC (4,4'-cyclohexylidenebis[N,N-bis(4-methylphenyl) benzenamine]) sensors with the same cylindrical nanopore structures. The TFB sensor outstands the others in sensitivity and lifetime and it shows a sensing response (current variation ratio) of 13% to 100 ppb ammonia after 64 days of storage in air. A repeated sensing periods testing and a long-term measurement have also been demonstrated for the test of robustness. The performance of the TFB sensor is stable in both tests, which reveals that the TFB sensor can be utilized in our targeting clinical trials. In the last part of this work, we study the change of ammonia concentration in the breath of hemodialysis (HD) patients before and after dialysis. An obvious drop of breath ammonia concentration can be observed after dialysis. The reduction of breath ammonia is also correlated with the reduction of blood urea nitrogen (BUN). A correlation coefficient of 0.82 is achieved. The result implies that TFB sensor may be. used as a real-time and low cost breath ammonia sensor for the daily tracking of hemodialysis patients.
URI: http://dx.doi.org/10.1021/acssensors.7b00564
http://hdl.handle.net/11536/144302
ISSN: 2379-3694
DOI: 10.1021/acssensors.7b00564
期刊: ACS SENSORS
Volume: 2
起始頁: 1788
結束頁: 1795
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