標題: miRTarBase update 2018: a resource for experimentally validated microRNA-target interactions
作者: Chou, Chih-Hung
Shrestha, Sirjana
Yang, Chi-Dung
Chang, Nai-Wen
Lin, Yu-Ling
Liao, Kuang-Wen
Huang, Wei-Chi
Sun, Ting-Hsuan
Tu, Siang-Jyun
Lee, Wei-Hsiang
Chiew, Men-Yee
Tai, Chun-San
Wei, Ting-Yen
Tsai, Tzi-Ren
Huang, Hsin-Tzu
Wang, Chung-Yu
Wu, Hsin-Yi
Ho, Shu-Yi
Chen, Pin-Rong
Chuang, Cheng-Hsun
Hsieh, Pei-Jung
Wu, Yi-Shin
Chen, Wen-Liang
Li, Meng-Ju
Wu, Yu-Chun
Huang, Xin-Yi
Ng, Fung Ling
Buddhakosai, Waradee
Huang, Pei-Chun
Lan, Kuan-Chun
Huang, Chia-Yen
Weng, Shun-Long
Cheng, Yeong-Nan
Liang, Chao
Hsu, Wen-Lian
Huang, Hsien-Da
生物科技學系
生物資訊及系統生物研究所
分子醫學與生物工程研究所
Department of Biological Science and Technology
Institude of Bioinformatics and Systems Biology
Institute of Molecular Medicine and Bioengineering
公開日期: 4-Jan-2018
摘要: MicroRNAs (miRNAs) are small non-coding RNAs of similar to 22 nucleotides that are involved in negative regulation of mRNA at the post-transcriptional level. Previously, we developed miRTarBase which provides information about experimentally validated miRNA-target interactions (MTIs). Here, we describe an updated database containing 422 517 curated MTIs from 4076 miRNAs and 23 054 target genes collected from over 8500 articles. The number of MTIs curated by strong evidence has increased similar to 1.4-fold since the last update in 2016. In this updated version, target sites validated by reporter assay that are available in the literature can be downloaded. The target site sequence can extract new features for analysis via a machine learning approach which can help to evaluate the performance of miRNA-target prediction tools. Furthermore, different ways of browsing enhance user browsing specific MTIs. With these improvements, miRTarBase serves as more comprehensively annotated, experimentally validated miRNA-target interactions databases in the field of miRNA related research. miRTarBase is available at http://miRTarBase.mbc.nctu.edu.tw/.
URI: http://dx.doi.org/10.1093/nar/gkx1067
http://hdl.handle.net/11536/144338
ISSN: 0305-1048
DOI: 10.1093/nar/gkx1067
期刊: NUCLEIC ACIDS RESEARCH
Volume: 46
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