標題: Fluorescent supramolecular hydrogels self-assembled from tetraphenylethene (TPE)/single amino acid conjugates
作者: Chu, Nien-Tzu
Chakravarthy, Rajan Deepan
Shih, Nai-Chia
Lin, Yen-Hsu
Liu, Yen-Chu
Lin, Jhong-Hua
Lin, Hsin-Chieh
材料科學與工程學系
Department of Materials Science and Engineering
公開日期: 1-Jan-2018
摘要: Herein, we report the synthesis of simple TPE/single amino acid conjugates, TPE-Ser and TPE-Asp with side-chains featuring functional groups that may provide an additional hydrogen bonding network for hydrogelation in aqueous medium. TPE-Ser, which has the lowest molecular weight, containing hydroxyl groups undergoes self-assembly into supramolecular hydrogels under physiological pH conditions. TPE-Asp with a carboxylic group side chain undergoes the self-assembly and hydrogelation processes under slightly acidic conditions (pH = 6.0). UV-vis, IR, PL and rheological studies clearly indicate the formation, stability and fluorescence properties of TPE-amino acid hydrogels. TEM micrographs of the hydrogels indicate that the compounds are self-assembled into a nanosheet morphology with random size and shape. Further, in vitro analysis of TPE-Ser and TPE-Asp with 3A6 cells shows that the compounds exhibit unique fluorescence signals in microcellular environments thus making them suitable candidates for bioimaging applications. Overall, these findings highlight the importance of the structure-hydrogelation relationship and provide new insights into the design of single amino-acid-based supramolecular hydrogels.
URI: http://dx.doi.org/10.1039/c8ra02296h
http://hdl.handle.net/11536/145108
ISSN: 2046-2069
DOI: 10.1039/c8ra02296h
期刊: RSC ADVANCES
Volume: 8
起始頁: 20922
結束頁: 20927
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